… High glucose levels in diabetic nephropathy mobilize the Rho pathway in mesangial cells,
and … Furthermore, glucose-induced Rac1 stimulation contributed to renal MR activation in …

… tissue damage, released by mesangial cells, and has been shown … study was to examine
the effect of a TNF-α inhibitor in the … Also, not shown are transactivation processes of PDGFRs …

… , particularly in hypertensive and diabetic nephropathy. The blockade … (AT1R) in murine
mesangial cells could result in activation of the EGF … Since the AT1R can transactivate the EGFR, …

… proliferation is blocked by Src inhibition. As Src family kinases are involved in EGFR
transactivation via ADAM … In mesangial cells, glucose promotes HB-EGF shedding and …

… As is widely known that p38/mitogen-activated protein kinase (MAPK) is an important kinase
… -induced diabetic mice. SB, a specific p38/MAPK inhibitor showed a marked inhibition of …

… epithelial cells is a major feature of diabetic kidney disease, … of BBR on high glucose-induced
apoptosis were explored … can inhibit HG-induced apoptosis in NRK-52E and HK-2 cells by …

… in mesangial cells (MC) in response to high glucose (HG). … diabetic nephropathy and
its 225 ability to transactivate the … ADAM17 inhibition with TAPI2 299 prevented glucose-induced …

… protected HK-2 cells from high glucose-induced cell damage. In … of Suoquan pill on diabetic
kidney disease by utilizing a … , which prevented lipid peroxidation in mesangial cells grown in …

… type IV collagen) and attenuates renal fibrosis in mice with … through inhibition of HIF-1α
signaling in mesangial cells [117]. … coupled bile acid receptor prevents oxidative stress and lipid …

… in STZ-induced diabetes rats prevented the onset of early … in early stage diabetic nephropathy
mice. More importantly, … telmisartan inhibited hyperglycemia or high-glucose induced …