Insulin effects in muscle and adipose tissue

G Dimitriadis, P Mitrou, V Lambadiari, E Maratou… - Diabetes research and …, 2011 - Elsevier
… In skeletal muscle and adipose tissue, three glucose … In a study in rats [18], the insulin-mediated
suppression of skeletal mus… Thyroid hormone excess and glucose intolerance. Exp Clin …

Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity

JWE Jocken, EE Blaak - Physiology & behavior, 2008 - Elsevier
… The latter may inhibit insulin signalling and play a role in the development of type 2 diabetes
The increased adipose tissue mass and a reduced insulin-mediated suppression of lipolysis

Role of lipid-derived mediators in skeletal muscle insulin resistance

A Taube, K Eckardt, J Eckel - American Journal of …, 2009 - journals.physiology.org
… of increased adipose tissue mass on skeletal muscle (SkM) … Hence, insulin-mediated glucose
uptake may be reduced or … from diet-induced glucose intolerance despite a high level of …

Metabolic fluxes in skeletal muscle in relation to obesity and insulin resistance

EE Blaak - Best Practice & Research Clinical Endocrinology & …, 2005 - Elsevier
fatty acid handling may relate to impaired adipose tissue … role of skeletal muscle in whole-body
insulin-mediated glucose … that obese subjects with impaired glucose tolerance and obese

Insulin action in morbid obesity: a focus on muscle and adipose tissue

P Mitrou, SA Raptis, G Dimitriadis - Hormones, 2013 - Springer
… for insulin-mediated glucose uptake in vivo,2,24 whereas … is impaired in both skeletal muscle
and adipose tissue, a … determined by an intravenous glucose tolerance test.Other studies ex …

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction

G Boden, GI Shulman - European journal of clinical …, 2002 - Wiley Online Library
Adipose tissue has been proposed to be a site of … in insulin-mediated suppression of
lipolysis leading to increased circulating FFA and ultimately insulin resistance in skeletal muscle

Effect of physical training on insulin secretion and action in skeletal muscle and adipose tissue of first-degree relatives of type 2 diabetic patients

F Dela, B Stallknecht - American Journal of Physiology …, 2010 - journals.physiology.org
… would increase insulin-mediated glucose uptake rates across … All subjects had normal
glucose tolerance as assessed by a … and femoral adipose tissue, insulin suppressed lipolysis

Mechanisms underlying the onset of oral lipid–induced skeletal muscle insulin resistance in humans

B Nowotny, L Zahiragic, D Krog, PJ Nowotny… - Diabetes, 2013 - Am Diabetes Assoc
… Screening included a standardized 75-g oral glucose tolerance … , assessed from insulin-mediated
suppression of EGP, was … adipose tissue inflammation does not seem to be involved. …

Insulin: The master regulator of glucose metabolism

L Norton, C Shannon, A Gastaldelli, RA DeFronzo - Metabolism, 2022 - Elsevier
… protein, skeletal muscle function is heavily reliant on the insulin-mediated uptake of glucose
and … through primary effects on adipose tissue lipolysis and free fatty acid (FFA) availability. …

Energy metabolism of white adipose tissue and insulin resistance in humans

K Bódis, M Roden - European journal of clinical investigation, 2018 - Wiley Online Library
… impaired insulin-mediated suppression of lipolysis and … insulin sensitivity of adipose tissue
vs skeletal muscle and liver … steatosis, impaired glucose tolerance, partial lipodystrophy and …