Insulin resistance in obesity as the underlying cause for the metabolic syndrome

EJ Gallagher, D LeRoith… - Mount Sinai Journal of …, 2010 - Wiley Online Library
… of insulin-mediated glucose uptake by skeletal muscle. In … a link between obesity, glucose
intolerance, and hypertension. … the β cells and the liver, skeletal muscle, and adipose tissue. …

Black African men with early type 2 diabetes have similar muscle, liver and adipose tissue insulin sensitivity to white European men despite lower visceral fat

O Bello, C Mohandas, F Shojee-Moradie, N Jackson… - Diabetologia, 2019 - Springer
… body, skeletal muscle, hepatic or adipose tissue insulin sensitivity … Insulin-mediated peripheral
glucose uptake (a), suppression … [39], suggesting that by the end of the glucose tolerance

Role of adipose tissue insulin resistance in the natural history of type 2 diabetes: results from the San Antonio Metabolism Study

A Gastaldelli, M Gaggini, RA DeFronzo - Diabetes, 2017 - Am Diabetes Assoc
… from normal glucose tolerance (NGT) to type 2 diabetes … In obese subjects without diabetes
and with type 2 diabetes … to show that in man, the suppression of lipolysis and FFA release is …

Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes

GF Lewis, A Carpentier, K Adeli, A Giacca - Endocrine reviews, 2002 - academic.oup.com
… role of abnormal fatty acid metabolism in skeletal muscle and … basal lipolytic rate in adipose
tissue from obese individuals (… in insulin-mediated suppression of fasting lipolysis vs. control …

[HTML][HTML] Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease

S Klein, L Fontana, VL Young… - … England Journal of …, 2004 - Mass Medical Soc
… sensitivity of liver, skeletal muscle, and adipose tissue (with a … Obese women with normal
glucose tolerance and those with … on glucose production and lipolysis (stage 1) and on glucose

[PDF][PDF] Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

RJ Perry, JPG Camporez, R Kursawe, PM Titchenell… - Cell, 2015 - cell.com
… were responsible for insulin-mediated suppression of HGP, … was $100% in liver, skeletal
muscle, and kidney, but only $65… , all subjects underwent an oral glucose tolerance test and a …

Pathogenesis and pathophysiology of the cardiometabolic syndrome

EP Kirk, S Klein - The Journal of Clinical Hypertension, 2009 - Wiley Online Library
… with obesity does not completely compensate for adipose tissue … liver and impaired
insulin-mediated suppression of hepatic glucosefat content is associated with skeletal muscle

Role of beta-cell dysfunction, ectopic fat accumulation and insulin resistance in the pathogenesis of type 2 diabetes mellitus

A Gastaldelli - Diabetes research and clinical practice, 2011 - Elsevier
… Insulin stimulates glucose uptake mainly in skeletal muscleinsulin-mediated glucose uptake.
The case of intramuscular … inhibition of lipolysis (insulin resistance of the adipose tissue) …

Metabolic flexibility in the development of insulin resistance and type 2 diabetes: effects of lifestyle

E Corpeleijn, WHM Saris, EE Blaak - obesity reviews, 2009 - Wiley Online Library
adipose tissue when adipose tissue blood flow is increased pharmacologically (26). Additionally,
an insulin-mediated increase in skeletal musclemen with impaired glucose tolerance (…

Basic disturbances in skeletal muscle fatty acid metabolism in obesity and type 2 diabetes mellitus

EE Blaak - Proceedings of the Nutrition Society, 2004 - cambridge.org
adipose tissue stores, increased triacylglycerol storage in … of impaired glucose tolerance
into type 2 diabetes mellitus. It … with insulin-mediated glucose uptake by muscle cells through …