A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based …

A Latva-Rasku, MJ Honka, A Stančáková… - Diabetes, 2018 - Am Diabetes Assoc
… years, BMI 20–40 kg/m 2 , and an oral glucose tolerance test … adipose tissue types, with
subcutaneous adipose tissue ROIs … insulin-mediated GU in skeletal muscle, liver, brown adipose

Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance

RCR Meex, MJ Watt - Nature Reviews Endocrinology, 2017 - nature.com
… resistance in skeletal muscle, hepatic and adipose tissues … HDL, glucose intolerance, insulin
resistance and type 2 diabetesglucose disposal, reduced insulin-mediated suppression of …

Defects in insulin secretion and action in the pathogenesis of type 2 diabetes mellitus

D Tripathy, AO Chavez - Current diabetes reports, 2010 - Springer
… action in the skeletal muscle, liver, and the adipose tissue. … 75% to 80% of glucose uptake
occurs in skeletal muscle [3]. … reduced insulin-mediated glucose uptake in type 2 diabetes. …

[HTML][HTML] Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus

MS Burhans, DK Hagman, JN Kuzma… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
The objective of this comprehensive review is to summarize and discuss the available evidence
of how adipose tissue inflammation affects insulin sensitivity and glucose tolerance. Low-…

Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms

E Bugianesi, A Gastaldelli, E Vanni, R Gambino… - Diabetologia, 2005 - Springer
… curve for insulin-mediated suppression of endogenous glucoseadipose tissue. However,
we cannot exclude a degree of independent resistance in the liver and skeletal muscle tissues

[HTML][HTML] Adenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin resistance in normal rats

H Satoh, MTA Nguyen, PDG Miles… - The Journal of …, 2004 - Am Soc Clin Investig
… of insulin-mediated glucose disposal, … to glucose intolerance and postprandial
hyperinsulinemia associated with decreased insulin sensitivity in skeletal muscle, liver, and adipose

Fatty acids, obesity, and insulin resistance: time for a reevaluation

F Karpe, JR Dickmann, KN Frayn - Diabetes, 2011 - Am Diabetes Assoc
… (35,36) and with impaired glucose tolerance (37). Hepatic insulin … In skeletal muscle, an
increase in intramyocellular lipid (… , abdominally obese men with 2.5 times the adipose tissue

Increased whole‐body adiposity without a concomitant increase in liver fat is not associated with augmented metabolic dysfunction

F Magkos, E Fabbrini, BS Mohammed, BW Patterson… - …, 2010 - Wiley Online Library
… groups were detected in insulin-mediated suppression of … in the liver, skeletal muscle, and
adipose tissue is inversely … electrocardiogram, and a 2-h oral glucose tolerance test. Exclusion …

Effects of acetate on lipid metabolism in muscles and adipose tissues of type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats

H Yamashita, H Maruta, M Jozuka, R Kimura… - Bioscience …, 2009 - jstage.jst.go.jp
… of acetate on skeletal muscle and adipose tissues. Treatment … skeletal muscle, and of lipolytic
genes in white and brown … of obesity and glucose tolerance by acetate in type 2 diabetic

Effects of insulin and exercise training on FGF21, its receptors and target genes in obesity and type 2 diabetes

R Kruse, SG Vienberg, BF Vind, B Andersen, K Højlund - Diabetologia, 2017 - Springer
… the insulin-mediated regulation of FGF21 in muscle and … in skeletal muscle of non-obese
individuals with impaired … , expression of CIDEA in adipose tissue was inversely related to …