Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in …

L Zhang, N Yang, JW Park, D Katsaros, S Fracchioli… - Cancer research, 2003 - AACR
… and that this effect is mediated by VEGFR-2. Tumor-derived … and VEGF188; the VEGFR-1
flt-1; the VEGFR-2 flk-1/KDR; … receptor-1/flt-1 and coreceptor neuropilin-1 but not Angs or their …

Modulation of VEGF expression in rat bone marrow stromal cells by GDF-5

K Sena, DR Sumner, AS Virdi - Connective tissue research, 2007 - Taylor & Francis
… by neuropilin 2 that exhibited a parallel profile to VEGF-D. … in vivo; VEGF-A and -B for blood
vessel formation and VEGF-… of VEGFR-2 and -3 in rBMSC; however, mRNA for VEGFR-1 was …

Increased plasma vascular endothelial growth factor (VEGF) as a surrogate marker for optimal therapeutic dosing of VEGF receptor-2 monoclonal antibodies

G Bocci, S Man, SK Green, G Francia, JML Ebos… - Cancer research, 2004 - AACR
… directed against mouse VEGFR-2 and VEGFR-1, respectively (… in vivo analysis of VEGF
secretion described above, the VEGF-… -binding receptors such as VEGFR-1 or neuropilin-1/2 (4), …

c-fos-induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro

L Marconcini, S Marchiò, L Morbidelli… - Proceedings of the …, 1999 - National Acad Sciences
… receptors VEGFR-2 and VEGFR-3. Here we report that Figf/… has been shown in human
endothelial cells that neuropilin-1 (… and the αvβ3 integrin associates with VEGFR-1 upon VEGF-A …

[HTML][HTML] A hybrid model for three-dimensional simulations of sprouting angiogenesis

F Milde, M Bergdorf, P Koumoutsakos - Biophysical journal, 2008 - cell.com
computational models of sprouting angiogenesis. In this work, we present the first three-dimensional
model of … different vascular endothelial growth factors isoforms on the dynamics and …

VEGF-directed blood vessel patterning: from cells to organism

VL Bautch - Cold Spring Harbor perspectives in …, 2012 - perspectivesinmedicine.cshlp.org
VEGFR-2, suggesting that VEGFR-1 acts to negatively modulate … major isoform has a
different capacity for matrix interactions. (… signaling in vivo using in situ probes. The evidence for …

Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine

S Ylä-Herttuala, TT Rissanen, I Vajanto… - Journal of the american …, 2007 - jacc.org
… Affinity to heparan sulfates and neuropilin co-receptors modulate the biological … (VEGFR-2)
or lymphangiogenic (VEGFR-3) properties (1,11,24). Interestingly, VEGFR-1 ligands VEGF-B …

Processing of VEGF-C and-D by the Proprotein Convertases

G Siegfried, AM Khatib - access.portico.org
… that exclusively activates VEGFR-2 but not VEGFR-1 or VEGFR-… in lymphendothelial cell
migration in vitro and in vivo (Figure 9) [… of complexes containing VEGFR-2 and neuropilin-1 that …

Vascular endothelial growth factor in the lung

NF Voelkel, RW Vandivier… - American Journal of …, 2006 - journals.physiology.org
… of VEGF have been demonstrated in in vitro and in vivo … PlGF regulates a number of genes
(136) including Flt-1, neuropilin-2, … out for VEGFR-1 but with intact VEGFR-2 (111). In addition, …

Design principles for therapeutic angiogenic materials

PS Briquez, LE Clegg, MM Martino… - Nature Reviews …, 2016 - nature.com
… co-receptor neuropilin 1 (NRP1) 54 . By contrast, the shorter … bound to the ECM than is free
in skeletal muscle 80 . Another … , in vivo systems and computational models. These efforts will …