… human immunodeficiency … IFN-γ, TNF-α, IL-2, or IL-12 produced spontaneously or in response
to anti-CD3 between the two groups. In addition, there were no differences in levels of IFN-…

… IFN-γ has been shown … , IL-12 and IL-23 are generally responsible for inducing RA.
Development of ustekinumab (Stelara), a humanized mAb that binds the shared p40 subunit of IL-12 …

… other genes involved in innate and adaptive immune responses, like gp91phox, IL-12/p40, …
-bet, which in turn promotes the expression of IL-12R and IFN-γ, creating a positive feedback …

… illness in patients with IL-12 deficiency or IL-12R deficiency. … of STAT-1 GOF, APDS1 and
APDS2 patients. Citation132 … programs for primary immunodeficiency diseases enable early …

… Activation of innate immune cells through PRRs also triggers … such as type I interferons
(IFNα/β), IL-12 and IFN-γ95. Antigen … interfaces between the surfaces of interacting immune cells, …

… agammaglobulinemia, is an inherited immunodeficiency disease caused by mutations in
the gene coding for Bruton tyrosine kinase (BTK). The disease was first elucidated by Bruton in …

… The importance of IFNγ and IL-12 in protection against disease was evident from the
increased risk of tuberculosis in individuals with deficiencies in either the IFNγ or IL-12 signaling …

… of TNF-α and IL-12, which in turn stimulates IFN-γ production by NK … Defects in IL-12R/IFN-γ
pathway are associated with … (HIE) syndrome may also reveal abnormalities in IL-12/IFNγ …

… Type 1 Interferon (T1IFN; IFNα/β), signalling via the phosphorylation of Signal Transduction
… for innate protection against viruses but also has diverse effects on the immune system. They …

… IL-12 to IFN-y and IFN-aẞ to IL-15 branches, because IL-12, … NK cell IFN-y production, and
the expression of type 1 IFN in… Interferon alpha increases the frequency of interferon gamma-…