… are associated with primary immunodeficiency, while loss of … they produce inflammatory
cytokines like TNF, IL-12 and IL-23. M2 … Inborn errors of IL-12/23- and IFN-γ-mediated immunity: …

… cells, which secrete cytokines that are involved in cell-mediated immune response (IFN-γ
and IL-12) or Th2 cells that secrete mediators of humoral immunity (IL-4 and IL-5) (Schluger et …

… , IFN-γ can act in an autocrine manner, as well as in a paracrine fashion if produced by IL-12-activated
NK cells, and promote expression of STAT-1 … for IL-12 p40 subunit or IL-12R were …

… priming for interferon gamma production and … IL-12 responsiveness at neutral conditions
shown by B10 T cells correlates with expression of the IL-12R B2 subunit, while loss of IL-12 …

… People living with human immunodeficiency virus or … mutations in the IFN-γ receptor 1, IL-12,
IL-12R and STAT1 who … of TH1 and IFN-γ secretion by CD4 T cells is dependent on IL-12, …

… The control of tuberculosis requires clearly delineated Th1 responses (IL-12, IFN-γ and TNF-α)
… immunodeficiency diseases: disorders of the interface of innate and adaptive immunity. …

… severe combined immunodeficiency disease SH2 … Hypersensitivity to pathogens due to
interferon- and IL-12-… Impaired type I and II interferon signalling, susceptibility to viral infections …

… Pathologic results show interface … , IL-12, and IFN-γ are increased in the peripheral blood
and inflammatory tissues in BD. Genetic studies have revealed upregulation of IL-23R, IL-12R, …

… T-cell proliferative and interferon gamma (IFNγ) responses to phytoheamaglutinin (PHA) …
We had expected to find evidence of a pro-inflammatory response (eg IL-1α, IL-1β, IL-6, IL-12) …

… DC activity is achieved through increased production of IL-‐12, IFN-‐γ and downstream …
Dendritic cells therefore form the critical interface between the innate and adaptive immune …