Role of the clinical laboratory in the diagnosis and management of malignant melanoma

RE SCOTT, DM WILSON - Mayo Clinic Proceedings, 1989 - Elsevier
pigmentary system to ultraviolet light prompted the conclusion that the assay of 5-S-cysteinyldopa
Measurement of levels of dopa and catecholamine in blood cells and plasma has also …

[HTML][HTML] Melanin Biopolymers in Pharmacology and Medicine—Skin Pigmentation Disorders, Implications for Drug Action, Adverse Effects and Therapy

M Karkoszka, J Rok, D Wrześniok - Pharmaceuticals, 2024 - mdpi.com
… Jakob Henle identified pigment cells in the human epidermis… , resulting in the formation of
2-S- and 5-S-cysteinylDOPA (CD)… DQ, leading to the formation of CD-quinones and DOPA (3,4-…

Melanin Chemistry

R Kishida, S Meñez Aspera, H Kasai, R Kishida… - … Chemistry Explored by …, 2021 - Springer
… in pigment cells, there are also melanin-like pigments in the … From the biodiversity
point of view, melanin-based pigmentation is … Pulse radiolysis of dopa with added 5-S-cysteinyldopa

Tyrosinase‐catalyzed metabolism of rhododendrol (RD) in B16 melanoma cells: production of RD‐pheomelanin and covalent binding with thiol proteins

S Ito, M Okura, Y Nakanishi, M Ojika… - Pigment cell & …, 2015 - Wiley Online Library
formation of dopaquinone with CySH or GSH, leading to the production of CyS-dopa or
GS-dopa… or medium (100 μl), and an internal standard 1.5 μM α-methyl-5-S-cysteinyldopa (MeCD…

Some Aspects of Melanin Formation of Melanocytes Cultured on Collagen‐Coated Microcarrier Beads

NPM Smit, W Westerhof, W Smit… - Pigment cell …, 1995 - Wiley Online Library
… In this respect, the precursor of phaeomelanin 5-S-cysteinyldopa (5s-CD) … of L-DOPA does
result in a dark pigmentation of the … Previously, we have shown the intracellular presence of 5,…

Synthesis and reactivity of phenolic systems conjugated with sulfidrylic compounds

G Greco - 2010 - fedoa.unina.it
… via the oxidative polymerization of 5-S-cysteinyldopa (5SCD). … melanin pigments, determining
black pigmentation was first … DOPA (DOPA-eumelanin) has no detectable effect on DOPA

The Mouse Brown (b) Locus Protein Functions as a Dopachrome Tautomerase

AJ Winder, A Wittbjer, G Odh, E Rosengren… - Pigment Cell …, 1994 - Wiley Online Library
… form eumelanin, and hence breakdown of hydrogen peroxide … other cell types, have a high
background level of dopachrome … In contrast, the level of 5-Scysteinyldopa, produced by the …

Neurotoxicity due to o-quinones: neuromelanin formation and possible mechanisms for o-quinone detoxification

F Solano, VJ Hearing, JC García-Borrón - Neurotoxicity Research, 1999 - Springer
… melanin, a protective pigment formed by different mechanisms … due to possible undesirable
reactions with other intracellular … of neuromelanin formation through 5-cysteinyl-dopa is just a …

Iron- and Manganese-Catalyzed Autoxidation of Dopamine in the Presence of l-Cysteine:  Possible Insights into Iron- and Manganese-Mediated Dopaminergic …

XM Shen, G Dryhurst - Chemical research in toxicology, 1998 - ACS Publications
… However, dopaminergic SN c cells are normally pigmented … result in heavier pigmentation
of dying SN c cells. However, … These responses would lead to elevated extracellular levels …

Fungal tyrosinases: new prospects in molecular characteristics, bioengineering and biotechnological applications

S Halaouli, M Asther, JC Sigoillot… - Journal of applied …, 2006 - academic.oup.com
… which associate in dark brown pigments. In fungi, tyrosinases … , and in browning and
pigmentation. First characterized from … formation of gluten‐bound 5ScysteinylDOPA and …