… process in MS. By means of a sensitive method to detect oligoclonal IgM bands in CSF and
… we have studied ITMS in patients with MS, other neurologic diseases, and control subjects. …

… a role for IgM antibodies in MS, such as the correlation of “de novo” … that intrathecal IgM
synthesis (ITMS) correlates with higher Expanded Disability Status Scale (EDSS) score in MS. In …

… of disability (as evaluated by means of the Expanded Disability … inverse correlation was
observed between the value of the IgM … further studies on the intrathecal IgM synthesis. Indeed, …

… and degree of disability (Kurtzke scale), disease progression … patients with various neurological
disorders who had been … intrathecal IgM synthesis is a reasonably good parameter of …

… the relationship between specificity and disease evolution. … increased disability compared
with those without anti-lipid IgM… other demyelinating diseases of the peripheral nervous system …

… intrathecal IgM synthesis is associated with a worse long-term prognosis. It also correlates
with a higher relapse rate, greater disability… identify relations between severity of disease in MS…

… disability milestones, in contrast to OCMB and IgM index. However, LS-OCMB provided a
2-fold significantly higher sensitivity than Reibergram, even if these results are probably …

… tool to OCGBs and as a risk factor for neurological disability and treatment failure. … to
progressive disease and long-term disability in MS (24). Comabella et al. showed a correlation …

… injection of serum IgM in the central nervous system results in … Therefore, the correlation
demonstrated in the present study … is a coherent clue to link IgM to long-term disability. As the …

… Disability Status Scale, IgG oligoclonal bands and disease-… and infectious diseases of the
central nervous system (CNS), … 13% 21 without any correlation with disability and inflammatory …