Termination of non‐coding transcription in yeast relies on both an RNA Pol II CTD interaction domain and a CTD‐mimicking region in Sen1
Z Han, O Jasnovidova, N Haidara, A Tudek… - The EMBO …, 2020 - embopress.org
… In addition, we show that Sen1-dependent termination strictly requires CTD recognition by …
action in the context of a kinetic competition between termination and elongation. We also find …
action in the context of a kinetic competition between termination and elongation. We also find …
[HTML][HTML] Single-molecule characterization of extrinsic transcription termination by Sen1 helicase
… statistical and kinetic analysis of Pol II interactions with a … the kinetics of extrinsic eukaryotic
transcription termination … cerevisiae RNA Polymerase II (Pol II) was purified from a strain that …
transcription termination … cerevisiae RNA Polymerase II (Pol II) was purified from a strain that …
[PDF][PDF] Sen1 is a key regulator of transcription-driven conflicts
U Aiello, D Challal, G Wentzinger, A Lengronne… - Molecular Cell, 2022 - cell.com
… RNA polymerase II at TRCs within genes and the rDNA and at sites of transcription-transcription …
We therefore first analyzed Sen1-dependent alterations on RNAPII distribution focusing …
We therefore first analyzed Sen1-dependent alterations on RNAPII distribution focusing …
[HTML][HTML] Genome-wide mapping of yeast RNA polymerase II termination
P Schaughency, J Merran, JL Corden - PLoS genetics, 2014 - journals.plos.org
… Pol II maintaining a pool of free enzyme able to compete for unoccupied promoters. Correct
termination also prevents Pol II … is depleted from the nucleus with similar kinetics (Figure 1C). …
termination also prevents Pol II … is depleted from the nucleus with similar kinetics (Figure 1C). …
Single-molecule characterization of Sen1 translocation properties provides insights into eukaryotic factor-dependent transcription termination
… RNA polymerase II (Pol II) complex. We quantify Sen1 translocation activity on single-stranded …
with kinetic competition models for Sen1-dependent termination of transcribing Pol II (6). …
with kinetic competition models for Sen1-dependent termination of transcribing Pol II (6). …
[PDF][PDF] Cell-cycle modulation of transcription termination factor Sen1
… -coding transcripts (ncRNA) generated by RNA polymerase II in S. cerevisiae are terminated
by … nous Sen1 is degraded with somewhat slower kinetics than the plasmid-encoded Sen1 (…
by … nous Sen1 is degraded with somewhat slower kinetics than the plasmid-encoded Sen1 (…
[PDF][PDF] Effects of transcription elongation rate and Xrn2 exonuclease activity on RNA polymerase II termination suggest widespread kinetic competition
… Here we investigate the universality of the torpedo model of pol II termination in human cells
… tested two central predictions of the torpedo model for RNA pol II transcription termination (…
… tested two central predictions of the torpedo model for RNA pol II transcription termination (…
[HTML][HTML] Disengaging polymerase: terminating RNA polymerase II transcription in budding yeast
HE Mischo, NJ Proudfoot - Biochimica et Biophysica Acta (BBA)-Gene …, 2013 - Elsevier
… DNA and releases its transcript. Initial scrutiny of protein-coding genes transcribed by RNA
Polymerase II (Pol II), … distinguish between controlled or scheduled transcription termination …
Polymerase II (Pol II), … distinguish between controlled or scheduled transcription termination …
A bacterial-like mechanism for transcription termination by the Sen1p helicase in budding yeast
O Porrua, D Libri - Nature structural & molecular biology, 2013 - nature.com
… We demonstrate that Sen1-dependent termination is exclusive for eukaryotic RNAPII and …
Therefore it is possible that transcription and Sen1p translocation compete kinetically and …
Therefore it is possible that transcription and Sen1p translocation compete kinetically and …
Transcription termination and the control of the transcriptome: why, where and how to stop
O Porrua, D Libri - Nature reviews Molecular cell biology, 2015 - nature.com
… , transcription initiation by RNA polymerase II (Pol II) occurs … the various termination pathways
for Pol II-dependent transcription, … to subtract mRNAs from competing nuclear degradation …
for Pol II-dependent transcription, … to subtract mRNAs from competing nuclear degradation …