The transcription cycle in eukaryotes: from productive initiation to RNA polymerase II recycling
J Shandilya, SGE Roberts - Biochimica et Biophysica Acta (BBA)-Gene …, 2012 - Elsevier
… Interestingly, TFIIA can compete with negative factors such … These bivalent histone marks
regulate the rapid induction kinetics … the Nrd1–Nab3–Sen1-dependent pathway. In eukaryotes, …
regulate the rapid induction kinetics … the Nrd1–Nab3–Sen1-dependent pathway. In eukaryotes, …
Getting up to speed with transcription elongation by RNA polymerase II
… transcripts and that reveal the positioning of RNA polymerase II (Pol II) have shown that the
pausing of Pol II in … are key steps in transcription regulation. Moreover, after the release of …
pausing of Pol II in … are key steps in transcription regulation. Moreover, after the release of …
[PDF][PDF] Knowing when to stop: transcription termination on protein-coding genes by eukaryotic RNAPII
JB Rodríguez-Molina, S West, LA Passmore - Molecular cell, 2023 - cell.com
… Here, we review eukaryotic transcription termination by RNA polymerase II (RNAPII), …
is a link between transcription termination and chromatin marks of active transcription.Readthrough …
is a link between transcription termination and chromatin marks of active transcription.Readthrough …
Nutrient-dependent control of RNA polymerase II elongation rate regulates specific gene expression programs by alternative polyadenylation
C Yague-Sanz, Y Vanrobaeys… - Genes & …, 2020 - genesdev.cshlp.org
… Transcription by RNA polymerase II (RNAPII) is a dynamic … in RNAPII elongation kinetics
has remained unclear. Here we … would increase the competition between proximal and distal …
has remained unclear. Here we … would increase the competition between proximal and distal …
Molecular basis for coordinating transcription termination with noncoding RNA degradation
A Tudek, O Porrua, T Kabzinski, M Lidschreiber… - Molecular cell, 2014 - cell.com
… Here we provide structural and functional evidence demonstrating that the same domain
of Nrd1p interacts with RNA polymerase II and Trf4p in a mutually exclusive manner, thus …
of Nrd1p interacts with RNA polymerase II and Trf4p in a mutually exclusive manner, thus …
The exosome component Rrp6 is required for RNA polymerase II termination at specific targets of the Nrd1-Nab3 pathway
MJ Fox, H Gao, WR Smith-Kinnaman, Y Liu… - PLoS …, 2015 - journals.plos.org
… by traditional polyA-dependent termination mechanisms [12,19]. RNA polymerase II (RNAPII)
transcription termination is coupled to 3’ end processing and carried out by two pathways […
transcription termination is coupled to 3’ end processing and carried out by two pathways […
Adventures in time and space: splicing efficiency and RNA polymerase II elongation rate
… A kinetic coupling model has been proposed in metazoans to describe how changing RNA
Polymerase II … , it logically follows that co-transcriptional splicing is instead in competition with …
Polymerase II … , it logically follows that co-transcriptional splicing is instead in competition with …
The role of Ctk1 kinase in termination of small non-coding RNAs
TL Lenstra, A Tudek, S Clauder, Z Xu, ST Pachis… - PLoS …, 2013 - journals.plos.org
… Transcription termination is essential for generating normal transcripts and for the release of
RNA Polymerase II (Pol II… notion of kinetic competition between transcription elongation and …
RNA Polymerase II (Pol II… notion of kinetic competition between transcription elongation and …
Wide-ranging and unexpected consequences of altered Pol II catalytic activity in vivo
… Here we employ a set of RNA Polymerase II (Pol II) … kinetic competition between transcription
termination and elongation in both yeast and human cells (19,20). Recently, a competition-…
termination and elongation in both yeast and human cells (19,20). Recently, a competition-…
The Nrd1-like protein Seb1 coordinates cotranscriptional 3′ end processing and polyadenylation site selection
JF Lemay, S Marguerat, M Larochelle… - Genes & …, 2016 - genesdev.cshlp.org
… Termination of RNA polymerase II (RNAPII) transcription is a … To determine whether
transcription kinetics contributes to poly… at the 3′ ends of genes may allow competition between …
transcription kinetics contributes to poly… at the 3′ ends of genes may allow competition between …