… driver of the SIRT1 signaling pathway which reverses the … reverse cholesterol transport and
bile acid biosynthesis. Cholesterol … to elucidate how they enhance longevity. We found that …

… The extended longevity of each of the three long-lived yeast … Planar and 3-D structures of a
bile acid called lithocholic acid… 50 Figure 2.11 Two signaling networks govern cellular aging …

… GPCR for secondary bile acids … to a wide variety of extrinsic and intrinsic signals. CSE is
induced by oxidative … In the long-lived Ames dwarf mice, which have reduced growth hormone (…

… XME genes is associated with lifespan extension in both sexes. … of those seen in mice where
GH signals are blocked in liver … the long-lived Ames dwarf mice. Biochem Biophys Res 504 …

… were observed in long-lived mutant mice and centenarians [… to an increase in secondary
bile acids and other metabolites … signaling, was demonstrated to result in lifespan extension in …

… certain pro-aging signaling pathways that control the rate of … a lasting exposure to exogenous
lithocholic bile acid (LCA) (… that extends longevity of each of the 3 selected long-lived yeast …

… to oxidative stress is observed in long-lived mammals, there is a … with insulin/IGF-I signaling
in lifespan prolongation, a limitation … lifespan in progeroid mice and alters lipid and bile acid …

… and maximum lifespan of adult mice fed a high-fat diet. This … gluconeogenesis and adiponectin
signaling, decreased … known to be altered in long-lived dwarf mice as well as by calorie …

… 3-keto bile acid-like steroids, called dafachronic acids, that … acid supplementation shortens
the life span of long-lived daf-9 … ‘pro-aging’ in response to signals from the dauer pathways. …

… with lifespan (Pickering et al., 2015). Upregulation of immunoproteosome components also
occurs in the liver of long-lived Snell dwarf mice and normal mice in which lifespan extension …