Loss of methylation in CpG sites in the NF‐κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes
MC De Andrés, K Imagawa, K Hashimoto… - Arthritis & …, 2013 - Wiley Online Library
… , we demonstrate that iNOS gene expression of human chondrocytes is regulated at the …
expression is mediated by the binding of NF-κB to the upstream sites of iNOS enhancer elements…
expression is mediated by the binding of NF-κB to the upstream sites of iNOS enhancer elements…
[HTML][HTML] Demethylation of an NF-κB enhancer element orchestrates iNOS induction in osteoarthritis and is associated with altered chondrocyte cell cycle
MC de Andrés, A Takahashi, ROC Oreffo - Osteoarthritis and Cartilage, 2016 - Elsevier
… loss of methylation that occurs at specific CpG sites localised at the −5.8 kb NF-κB enhancer
region of the iNOS gene … This catabolic factor is the product of inducible nitric oxide synthase …
region of the iNOS gene … This catabolic factor is the product of inducible nitric oxide synthase …
Genome-wide DNA methylation analysis of articular chondrocytes identifies TRAF1, CTGF, and CX3CL1 genes as hypomethylated in osteoarthritis
L Zhao, Q Wang, C Zhang, C Huang - Clinical Rheumatology, 2017 - Springer
… CpG sites of selected candidate hypomethylated genes: … participates in the NF-κB pathway
[18]. High levels of TRAF1 … ultimately to complete loss of articular cartilage. Previous studies …
[18]. High levels of TRAF1 … ultimately to complete loss of articular cartilage. Previous studies …
Role of histone methylation in the regulation of COX-2, iNOS, and mPGES-1 gene expression in human chondrocytes: Implication for Osteoarthritis
FE El Mansouri - 2016 - papyrus.bib.umontreal.ca
… bone remodeling resulting in a loss of joint function. These … E synthase-1 (mPGES-1),
inducible nitric oxide synthase (iNOS), … , articular cartilage is composed of two main elements: the …
inducible nitric oxide synthase (iNOS), … , articular cartilage is composed of two main elements: the …
DNA methylation regulates miR-140-5p and miR-146a expression in osteoarthritis
… methylated CpG sites near or within OA-related genes [2,3]. It … ), nor chondrocyte
dedifferentiation, as evidenced by lack of … that this hypermethylation was responsible for the …
dedifferentiation, as evidenced by lack of … that this hypermethylation was responsible for the …
[HTML][HTML] DNA methylation in osteoarthritic chondrocytes: a new molecular target
HI Roach, T Aigner - Osteoarthritis and cartilage, 2007 - Elsevier
… via nitric oxide (NO), since NO donors also caused gene … However, there were CpG sites,
where loss of methylation … proteases that are induced in OA have NF-κB binding sites in their …
where loss of methylation … proteases that are induced in OA have NF-κB binding sites in their …
[HTML][HTML] DNA methylation in osteoarthritis: current status and therapeutic implications
A Miranda-Duarte - The open rheumatology journal, 2018 - ncbi.nlm.nih.gov
… ) and Nitric Oxide Synthase (NOS… loss of methylation at specific CpG sites in the iNOS
promoter could not account for its abnormal expression; however, demethylation of specific NF-κB …
promoter could not account for its abnormal expression; however, demethylation of specific NF-κB …
[PDF][PDF] Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation
K Imagawa, MC De Andrés, K Hashimoto… - Arthritis & …, 2014 - Wiley Online Library
… Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide
synthase is responsible for gene induction in human articular chondrocytes. Arthritis Rheum …
synthase is responsible for gene induction in human articular chondrocytes. Arthritis Rheum …
Inflammation and epigenetic regulation in osteoarthritis
… Similarly, the CpG sites within the promoter area of a number of … an NF-κB-responsive
enhancer was shown to increase the expression of inducible nitric oxide synthase (iNOS), a gene …
enhancer was shown to increase the expression of inducible nitric oxide synthase (iNOS), a gene …
[HTML][HTML] Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis
A Takahashi, MC De Andrés, K Hashimoto, E Itoi… - … and cartilage, 2015 - Elsevier
… results in enhanced expression of IL8 and loss of DNA methylation … methylation of specific
CpG sites correlates with IL8 gene … the NF-κB p65 subunit played a critical role in induction of …
CpG sites correlates with IL8 gene … the NF-κB p65 subunit played a critical role in induction of …