Memory CD8+ T cells require CD28 costimulation

AB Borowski, AC Boesteanu, YM Mueller… - The Journal of …, 2007 - journals.aai.org
… , using two different approaches and two different viruses, we show that following infection in
vivo memory CD8 + T cells … expansion of memory CD8 + T cells, the generation of maximal …

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

EL Pearce, MC Walsh, PJ Cejas, GM Harms, H Shen… - Nature, 2009 - nature.com
… a critical role after infection by regulating a metabolic switch in CD8 T cells that promotes …
manipulated during an immune response to promote CD8 T M -cell generation and protective …

Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells

…, W Cui, RA Amezquita, SM Gray, T Guan… - Nature …, 2015 - nature.com
… You are using a browser version with limited support for CSS. To … lower percentage and
number of Il10ra f/f Cd4-Cre P14 cells … the generation and maturation of a phenotypically mature …

Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation

JJ Obar, ER Jellison, BS Sheridan, DA Blair… - The Journal of …, 2011 - journals.aai.org
… to infection, CD8+ T cells integrate multiple signals and undergo an exponential increase in
cell … SLEC generation was dependent on Ebi3 expression. Furthermore, SLEC differentiation …

… CD8+ T cell memory generation in Puumala hantavirus infection occurs after the acute phase and is associated with boosting of EBV-specific CD8+ memory T cells

T Tuuminen, E Kekäläinen, S Mäkelä… - The Journal of …, 2007 - journals.aai.org
… N protein-specific CD8 + T cells using HLA-A2 tetramers … takes place on the receptor level.
We analyzed the expression of IL… . Persistence of memory CD8 T cells in MHC class I-deficient …

Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria

NW Schmidt, RL Podyminogin… - Proceedings of the …, 2008 - National Acad Sciences
memory CD8 T cell generation that protects mice against multiple P. berghei sporozoite
challenges for at least 19 months. Using … of 10,000 memory CD8 T cells reduced infection by the …

Naive, effector, and memory CD8 T cells in protection against pulmonary influenza virus infection: homing properties rather than initial frequencies are crucial

A Cerwenka, TM Morgan, RW Dutton - The Journal of Immunology, 1999 - journals.aai.org
… For effector generation, CD8 T cells from the clone-4 … -induced cell death seen in vitro at least
at the population level, and we are … protocols using Ag-specific CD8 T cell populations (44). …

Regulatory T Cells Increase the Avidity of Primary CD8+ T Cell Responses and Promote Memory

…, F Lemaitre, P Bousso, L Fetler, T Sparwasser… - Science, 2012 - science.org
using CD69 expression (fig. S5A), which suggests that … memory CD8 + cells (Fig. 4, E and
F). Therefore, the presence of … For memory T cell generation, naïve and 50-days postinfection …

Induction and visualization of mucosal memory CD8 T cells following systemic virus infection

SK Kim, KS Schluns, L Lefrançois - The Journal of Immunology, 1999 - journals.aai.org
… issues regarding T cell activation and memory generation. In a … not shown) after primary
activation, and the level of CD44 … of a T cell memory response could be induced using oral Ag, …

Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection

DJ Shedlock, JK Whitmire, J Tan… - The Journal of …, 2003 - journals.aai.org
… In this study, we examined these questions using an … To examine the generation of
epitope-specific CD8 T cells, … We next investigated whether gp33-specific memory CD8 T cells