Strategies and implications for prime-boost vaccination to generate memory CD8 T cells

JC Nolz, JT Harty - Crossroads between Innate and Adaptive Immunity III, 2011 - Springer
… of primary memory CD8 T cells during an acute infection with … require the generation of
protective memory CD8 T cells. It is … would manipulate memory CD8 T cell localization following

Kinetics of Virus-Specific CD8+ T Cells and the Control of Human Immunodeficiency Virus Infection

MP Davenport, RM Ribeiro, AS Perelson - Journal of virology, 2004 - Am Soc Microbiol
rates of tetramer-positive cells were also determined using a … of memory CD8 + T cells may
lead to lower T-cell avidity. Any … + T cells are required for optimal generation of CD8 + T-cell

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells

SM Kaech, R Ahmed - Nature immunology, 2001 - nature.com
… of cellular fluorescent intensity with each successive generation. … by P14 CD8 + T cells 1
and 7 days after infection was … P14 CD8 + T cells were purified using CD8α magnetic beads …

Memory CD8+ T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection

NH Shoukry, A Grakoui, M Houghton… - The Journal of …, 2003 - rupress.org
… of viral infection and T cell–mediated immune responses using an … We cannot exclude the
possibility of low level virus … efficient generation of primary but not secondary T cell responses. …

CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death

EM Janssen, NM Droin, EE Lemmens, MJ Pinkoski… - Nature, 2005 - nature.com
… of CD4 + T cells in the generation of CD8 + T cell memory and … In conclusion, by using a
range of antigenic challenges, our … CD8 + T cells from LCMV-infected mice were stimulated for 7 …

Autophagy is a critical regulator of memory CD8+ T cell formation

DJ Puleston, H Zhang, TJ Powell, E Lipina, S Sims… - Elife, 2014 - elifesciences.org
using the compound spermidine. This study reveals a … + T cell response to vaccination and
infection in elderly mice in … Defective generation but normal maintenance of memory T cells in …

IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection

JS Yi, JT Ingram, AJ Zajac - The Journal of Immunology, 2010 - journals.aai.org
… Although the generation of memory CD8 T cells, which are … following acute LCMV infection,
effector and memory CD8 T … were determined by flow cytometric analysis using a panel of …

The timing of stimulation and IL-2 signaling regulate secondary CD8 T cell responses

SH Khan, MD Martin, GR Starbeck-Miller… - PLoS …, 2015 - journals.plos.org
generation and development of 2 memory (M) CD8 T cells. … M CD8 T cell differentiation is
not fixed and can be manipulated… time at which primary memory CD8 T cells encounter antigen …

Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections

MA Brehm, TG Markees, KA Daniels… - The Journal of …, 2003 - journals.aai.org
… Cross-reactive LCMV-specific CD8 T cells were directly visualized using … the generation of
allo-specific memory CD8 T cells by virus … the percentage of CD8 T cells producing IFN-γ. The …

[HTML][HTML] Molecular and functional profiling of memory CD8 T cell differentiation

SM Kaech, S Hemby, E Kersh, R Ahmed - Cell, 2002 - cell.com
infected with LCMV-Armstrong. Pure populations of “resting” naı̈ve, effector, and memory
P14 CD8 T cells were isolated using … be important for generating memory cell phenotypes as …