Imaging intratumor heterogeneity: role in therapy response, resistance, and clinical outcome

JPB O'Connor, CJ Rose, JC Waterton… - Clinical Cancer …, 2015 - AACR
… (DSC-MRI) in patients with high-grade glioma (HGG) to map relative cerebral blood volume
(… to highest malignant grade and that this improves prognostic assessment in patients. It is …

Bevacizumab for malignant gliomas: current indications, mechanisms of action and resistance, and markers of response

R Tamura, T Tanaka, K Miyake, K Yoshida… - Brain tumor pathology, 2017 - Springer
Response Assessment in Neuro-Oncology (RANO) Group proposed new recommendations
for evaluating the treatment response of high-grade gliomas … to evaluate tumor response or …

Development of a multiparametric voxel-based magnetic resonance imaging biomarker for early cancer therapeutic response assessment

CJ Galbán, B Lemasson, BA Hoff, TD Johnson… - Tomography, 2015 - mdpi.com
response following chemoradiotherapy in glioma patients. A … response map (PRM), was
applied to quantitative MRI maps … criteria for phase II studies of supratentorial malignant glioma

Phenotypic mapping of pathologic cross-talk between glioblastoma and innate immune cells by synthetic genetic tracing

MJ Schmitt, C Company, Y Dramaretska, I Barozzi… - Cancer discovery, 2021 - AACR
glioblastoma, synthetic genetic tracing causally connects cellular and molecular heterogeneity
to therapeutic responses… IDH1 status in patients with high-grade glioma and are hereafter …

Parametric Response Map (PRM) Analysis Improves Response Assessment in Gliomas

M Cardenas, CJ Galban, TL Chenevert… - Glioma Imaging …, 2020 - Springer
… of treatment response in gliomas, which has the potential to improve individualized
patient therapy [28]. … of pseudoprogression in malignant gliomas. Lancet Oncol. 2008;9(5):453–61. …

Strategy of surgical resection for glioma based on intraoperative functional mapping and monitoring

M Tamura, Y Muragaki, T Saito, T Maruyama… - Neurologia medico …, 2015 - jstage.jst.go.jp
… , functional information from brain mapping and monitoring, … minimally invasive surgical
treatment of glioma. Intraoperative … of patient response for neurofunctional mapping and …

MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival

T Demuth, LB Reavie, JL Rennert, M Nakada… - … cancer therapeutics, 2007 - AACR
… The operational fluctuation between invasion and proliferation as a working hypothesis in
malignant glioma pathobiology is supported by the finding that tumor recurrence often occurs …

Emerging methods for disease monitoring in malignant gliomas

P Ambady, C Bettegowda, M Holdhoff - CNS oncology, 2013 - Future Medicine
… disease burden and treatment response in individuals with malignant gliomas. Traditional …
maps (functional diffusion maps), and rCBV derived from DSC-MRI parametric response map

[HTML][HTML] Current FDA-approved therapies for high-grade malignant gliomas

JP Fisher, DC Adamson - Biomedicines, 2021 - mdpi.com
… and allows for intraoperative visualization of malignant glioma tissue via fluorescence-guided …
The new genomic era has made it possible to map individual patient glioma genomes and …

[HTML][HTML] High-grade glioma treatment response monitoring biomarkers: a position statement on the evidence supporting the use of advanced MRI techniques in the …

OM Henriksen, M del Mar Álvarez-Torres… - Frontiers in …, 2022 - frontiersin.org
treatment, “monitoring biomarkers” are measured serially and are required to detect any change
in the extent of glioma infiltration or provide evidence of treatment response (… rCBV maps