Involvement of decreased hypoxia-inducible factor 1 activity and resultant G1–S cell cycle transition in radioresistance of perinecrotic tumor cells
Y Zhu, T Zhao, S Itasaka, L Zeng, CJ Yeom, K Hirota… - Oncogene, 2013 - nature.com
… the production of reactive and cytotoxic species by ionizing … employed a plasmid expressing
a fusion protein, p27 Kip1 -myc … /mTOR pathway assures the synthesis of HIF-1alpha protein …
a fusion protein, p27 Kip1 -myc … /mTOR pathway assures the synthesis of HIF-1alpha protein …
[HTML][HTML] SPINK1 as a plasma marker for tumor hypoxia and a therapeutic target for radiosensitization
T Suwa, M Kobayashi, Y Shirai, JM Nam, Y Tabuchi… - JCI insight, 2021 - ncbi.nlm.nih.gov
… and radiobiological mechanisms (3), ultimately having a … various types of DNA damage
including DNA double-strand … expresses a fusion protein of EGFP and 53 binding protein 1 …
including DNA double-strand … expresses a fusion protein of EGFP and 53 binding protein 1 …
Detection of the Onset of Ischemia and Carcinogenesis by Hypoxia-Inducible Transcription Factor-Based In Vivo Bioluminescence Imaging
T Kadonosono, T Kuchimaru, S Yamada, Y Takahashi… - PLoS …, 2011 - journals.plos.org
… (Pro402 and Pro564) located in the HIF… fusion protein consisting of the nuclear localization
signal (NLS) of the simian vacuolating virus 40 T-antigen, the oxygen-dependent degradation …
signal (NLS) of the simian vacuolating virus 40 T-antigen, the oxygen-dependent degradation …
Viral-based gene delivery and regulated gene expression for targeted cancer therapy
Y Lu, CO Madu - Expert Opinion on Drug Delivery, 2010 - Taylor & Francis
… cancer cells with no or minimal damage to the host body is … cytotoxic genes can be used
specifically to target the hypoxic … , procaspase-3, was chosen to result in the fusion protein Tat-…
specifically to target the hypoxic … , procaspase-3, was chosen to result in the fusion protein Tat-…
A Novel Hypoxia Imaging Endoscopy System
K Kaneko, H Yamaguchi, T Yano - Hypoxia and Human …, 2017 - books.google.com
… with neuropathy and acute toxicity on the CNS [33]. … over the years; meanwhile, hypoxia-specific
agents have also been … as HIF-1α, PTD-ODD fusion proteins are thought likely to be co-…
agents have also been … as HIF-1α, PTD-ODD fusion proteins are thought likely to be co-…
PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase
M Inoue, M Yoshimura, M Kobayashi, A Morinibu… - Scientific reports, 2015 - nature.com
… browser (or turn off compatibility mode in Internet Explorer). In … PLK1 blockade enhanced
the cytotoxic effects of radiation by … damage responses through the regulation of p53 binding …
the cytotoxic effects of radiation by … damage responses through the regulation of p53 binding …
Multimodal Imaging of Pathophysiological Changes and Their Role in Development of Breast Cancer Brain Metastasis
D Zhao… - 2012 - apps.dtic.mil
… The views, opinions and/or findings contained in this report are those of the author(s) and
should … with tumor aggressiveness and understand pathoph ysiological mechanism underly …
should … with tumor aggressiveness and understand pathoph ysiological mechanism underly …