Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic development

H Kim, L Pawlikowska, Y Chen, H Su, GY Yang… - Stroke, 2009 - Am Heart Assoc
… , vascular endothelial growth factor) initiates microvascular growth and … Arteriovenous
shunting and high flow rates synergize with the dysplastic response and with inflammatory signals, …

Evidence of increased endothelial cell turnover in brain arteriovenous malformations

T Hashimoto, R Mesa-Tejada, CM Quick… - …, 2001 - journals.lww.com
… are dynamic lesions with active angiogenesis or vascular … nonspecific inflammatory
processes might have been active. … The BAVM nidus is perfused at high flow rates with arterial …

Contemporary management of vascular malformations

G Colletti, D Valassina, D Bertossi, F Melchiorre… - Journal of Oral and …, 2014 - Elsevier
Swelling is a consistently occurring side effect of … because it lacks the bruising and pulsations
of a high-flow lesion, it is not … most frequent high-flow vascular malformation and accounts …

The current management of vascular birthmarks

O Enjolras, JB Mulliken - Pediatric dermatology, 1993 - Wiley Online Library
… an arteriovenous malformation because both are high-flow lesiotis. … girl with a 10-year history
of swelling, warmth, and pain in the … Local flap transposition, microvascular flap transfer, or …

Agminated pyogenic granuloma–like growth arising in a congenital hemangioma

B Barrick, J Lehman, M Tollefson - JAMA dermatology, 2014 - jamanetwork.com
Microvascular proliferation and PGs may occur commonly in AVMs owing to the high-flow
properties of AVMs and … Microvascular proliferations in arteriovenous malformations

Vascular anomalies in pediatric patients: updated classification, imaging, and therapy

R Kollipara, A Odhav, KE Rentas… - Radiologic …, 2013 - radiologic.theclinics.com
… of cells within the lesion. Conversely, vascular malformations grow with the child and may
enlarge as a result of vessel distention caused by hemorrhage, infection, or inflammation. …

Pathogenesis of non-hereditary brain arteriovenous malformation and therapeutic implications

T Ota, M Komiyama - Interventional Neuroradiology, 2020 - journals.sagepub.com
inflammatory lesion, rather than a static congenital vascular … PI3K pathway in high-flow
AVMs have not previously emerged. … molecular cross-talk of microvasculature, may deepen our …

Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations

H Kim, DA Marchuk, L Pawlikowska, Y Chen, H Su… - Cerebral …, 2008 - Springer
… or angiogenic activity (MMP, VEGF) initiates microvascularArteriovenous (A–V) shunting
and high flow rates synergize with the dysplastic response and involve classical inflammatory

Cerebral arteriovenous malformations. Part 1: cellular and molecular biology

P Moftakhar, JS Hauptman, D Malkasian… - Neurosurgical focus, 2009 - thejns.org
… adhesion and ECM factors, inflammatory factors, MMPs, and … perfused with arterial blood at
high flow rates. Since the nidus … cells, and human microvascular cells. Furthermore, this high …

Surgical strategies for acutely ruptured arteriovenous malformations

JL Martinez, RL Macdonald - New Insights in Intracerebral Hemorrhage, 2016 - karger.com
… This arrangement creates a high-flow circulatory shunt with … hematoma liquefaction, and
inflammatory reactions to subside… venous anomalies and microvascular thrombosis, causing …