[PDF][PDF] Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point‐mutant β‐catenin

J Tao, E Xu, Y Zhao, S Singh, X Li, G Couchy… - …, 2016 - Wiley Online Library
… between the human differential expression analysis of this subset of HCC cases … mouse
model, we mapped mouse genes to their human orthologs according to the MGI mouse-human

[HTML][HTML] Experimental models of hepatocellular carcinoma

P Newell, A Villanueva, SL Friedman, K Koike… - Journal of …, 2008 - Elsevier
Mouse models of cancer were first introduced over 60 years ago. Shortly … Met transgenic
Tetracycline-inducible expressing human Met under liver-specific promoter crossed with mice

[PDF][PDF] An infernal cross‐talk between oncogenic β‐catenin and c‐Met in hepatocellular carcinoma: Evidence from mouse modeling

RM Pascale, F Feo, DF Calvisi - Hepatology, 2016 - Wiley Online Library
… catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad
Sci … Modeling a human HCC subset in mice through co-expression of Met and point-mutant b-…

[HTML][HTML] The effect of selective c-MET inhibitor on hepatocellular carcinoma in the MET-active, β-catenin-mutated mouse model

N Zhan, AA Michael, K Wu, G Zeng, A Bell, J Tao… - Gene …, 2018 - ncbi.nlm.nih.gov
Using a reductionist approach, we coexpressed c-MET and … to a subset of human HCC, and
the tumors displayed … be beneficial in a clinical subset where c-MET and β-catenin cooperate …

Overexpression of HGF promotes HBV-induced hepatocellular carcinoma progression and is an effective indicator for Met-targeting therapy

Q Xie, Y Su, K Dykema, J Johnson… - … & cancer, 2013 - journals.sagepub.com
… By using genetically engineered mouse models, we show that … was found to represent a
subset of human HCC that had an … There is co-expression of Met and HBsAg in the same …

[HTML][HTML] Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice

J Hu, L Che, L Li, MG Pilo, A Cigliano, S Ribback… - Scientific reports, 2016 - nature.com
… , we generated a model characterized by the combined … Co-expression of AKT and c-Met
triggered rapid liver tumor … AKT and c-Met oncogenes while deleting FASN in a subset of mouse

[HTML][HTML] The c-Met inhibitor MSC2156119J effectively inhibits tumor growth in liver cancer models

F Bladt, M Friese-Hamim, C Ihling, C Wilm, A Blaukat - Cancers, 2014 - mdpi.com
… malignancies, including hepatocellular carcinoma (HCC). … of a subset of HCC tumors
characterized by high c-Met expression … could be explained by co-expression of c-Met and HGF in …

[PDF][PDF] Synergistic role of sprouty2 inactivation and c‐Met up‐regulation in mouse and human hepatocarcinogenesis

SA Lee, S Ladu, M Evert, F Dombrowski… - …, 2010 - Wiley Online Library
… is frequently down-regulated in human hepatocellular carcinoma (HCC). … loss of Spry2
expression in a subset of human HCCs with … Our mouse model demonstrated that coexpression of …

Novel xenograft model expressing human hepatocyte growth factor shows ligand-dependent growth of c-Met–expressing tumors

TD Francone, RG Landmann, CT Chen, MY Sun… - Molecular cancer …, 2007 - AACR
… or remained elevated in a subset of patients with poor outcome. Our … and sustains
hepatocellular carcinomas in transgenic mice. … Tumorigenesis induced by coexpression of human

[HTML][HTML] Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway

Z Xu, J Hu, H Cao, MG Pilo, A Cigliano… - … & Molecular Medicine, 2018 - nature.com
… upregulation of c-Met occurs in a subset of human HCC, mainly … In this study, using
sgPten/c-Met mouse HCC model in … by sgPten/c-Met co-expression. mTORC2 regulates multiple …