… animal genome modification, … animals may have epigenetic abnormalities despite having
a normal phenotype at a young age. Therefore, we plan to follow our genome-modified animals …

… several domestic animals have been sequenced and annotated. Important uses of genomic
… ogies that allow precise modifications of the genome, including targeted chromosomal …

… domestic cat, domesticated and wild rabbit reveal a relatively increased density of a number
of mobile genetic elements in domesticated animals … repressive histone modifications at the …

… Developments in animal genomics have broadly followed the route that the human … and
diversified animal production systems. We anticipate genetically modified animals will soon play …

… health, the safety of a genetic modification to the plant itself has not been a concern of the
public. In contrast, the safety of a genetic modification to the animal is of greater interest to the …

… chemical modifications of DNA and chromatin proteins. Since the discovery of genomic
imprinting … While most genomic imprinting studies have focused on mouse models and human …

… used to develop some of the most important large animal models for biomedical research.
Advances in pig genome research, genetic modification (GM) of primary pig cells and pig …

… to using domestic animal models for … animals as dual-purpose animal models that benefit
agriculture and biomedicine will also be necessary. In conclusion, the broad diversity of animal …

… growth until the present, similar to other domestic animal species. Our data further suggest
that … domestic population; specifically, at least 46 of the mtDNA lineages observed in domestic …

… In summary, this study demonstrates that ZFNs are very efficient for gene editing of large
domestic animals as in other species. The high frequency of induced bi-allelic mutations should …