… Gene transfer can be used to modify the genome of domestic livestock. The use of gene …
the efficiency of animal agriculture as the demand for production increases. Animals that have …

… recombination event per cell modified can be as low as 1 in … domestic animals. To overcome
the problem associated with obtaining isogenic targeting constructs from domestic animals, …

… targeted genetic change in domestic animals as demonstrated by … modification in making
targeted genetic modifications in domestic animal models will be maximized if those genome …

… cloning permit the introduction of specific genetic modifications into the genome of domestic
animals. Although gene targeting in mouse ES cells has become a routine procedure in …

… genomic segments of various sizes. Chromosomal rearrangements can lead to significant
modifications … eg duplications and deletions) of genomic regions, shaping phenotypic variation …

… undergoes changes or lead to regulatory modification if the regulatory sequences of the …
and domesticated animals. However, the analysis of the genome sequence of domestic pigs …

… to modify the genome of farm animals, summarizes current knowledge on the underlying
mechanism, and discusses new opportunities for generating genetically modified farm animals. …

… such a variety of domestic animals can produce such similar … unique genomic properties
of domesticated animals that … domestic animals that can be thought of as modifying behavior. …

… to modify a genome via MS, and finally survey the growing literature on the utility of MS for
targeted genome modification. … from pigs and other domestic animals, preventing selection for …