… oncogenes and tumor-suppressor genes, including the genes for DNA … microsatellite DNA
instability in normal-appearing tissues adjacent to the tumor [20], suggesting that colorectal …

… as tumor suppressor genes, resulting in the development of malignancy [10]. Colon tumors
are … , usually observed as alterations in microsatellite sequences that reflect a malfunction in …

… loss of putative tumor suppressor genes, 7 and genetic instability, … to be a preneoplastic lesion
of the stomach, which is … to reports on mutations of p53 and APC genes in IM and dysplasia…

… instability pathway or the microsatellite instability pathway. In … of many genes, including
some tumor suppressor genes such … as tumors of the colorectum, endometrium, stomach, small …

… have been identified as attractive candidates for the new tumor suppressor genes: p21 (…
This suggests that microsatellite instability may occur as an early event of stomach …

… Diagnostically, p53 immunohistochemistry remains the only … of patients in which neoplastic
lesions are detected at early … In a more recent study, the LOH and microsatellite instability …

… , ovary, stomach, small bowel, ureter and renal pelvis. … Microsatellite instability can also
be caused by other genetic … the p53, Rb, and MCC/APC tumor suppressor gene loci in …

… Microsatellite instability has been reported to be absent or … as well as those of the stomach.
Mutations in other oncogenes… in APC, a tumor suppressor gene which plays a pivotal role in …

… in the initiation and progression of neoplasia. The 9p21 … (AI/LOH) in microsatellite markers
and observed a low percentage … be assigned to different molecular regulatory mechanisms (ie …