… , with the genetic defects, of initiation of tumorigenesis and tumor malignant progression …
for novel therapies, which could be tailored based on the genetic signature of the tumor and the …

… Based on the MTGs scores, we then classified 930 patients with pancreatic cancer into …
clinical outcomes and treatment strategies of different subgroups of pancreatic cancer patients. …

… This molecular pathway easily explains how TSC syndrome is associated with familial
pancreatic endocrine neoplasms. In mice models, TSC2+/− tumors display an mTOR-activation …

… ) is a novel treatment modality for advanced … strategy of coupling an isotope such as 177
Lu or 90 Y with a somatostatin analogue through a linker has been used to develop therapeutic …

… Integration of high-grade components and molecular markers successfully led to
categorization of 19 out of 20 ambiguous cases [29]. This example highlights the vital need for the …

… will provide us with new diagnostic and prognostic biomarkers, inform the development
of improved pre-clinical models, and identify novel therapeutic targets for GEP-NET patients. …

… Novel therapeutic options are crucially needed for relatively rare but deadly NETs… molecular
and cellular biology studies have radically modified our knowledge of neuroendocrine tumor …

… endocrine tumors, including thyroid, adrenal, pituitary, pancreatic, and gonadal carcinoma,
as … A variety of molecular marker test are also available in hospital-based laboratories for the …

… treatment of patients with pancreatic neuroendocrine tumors (… as well as other gastrointestinal
neuroendocrine tumors (GI-… in their understanding and treatment. pNETs are receiving …

… the aggressive tumors represents a finding of potential therapeutic … in NE tumors that respond
to novel therapeutic regimens … a genetic approach for the classification of NE tumors of the …