Systemic therapies in neuroendocrine tumors and novel approaches toward personalized medicine

ME Pavel, C Sers - Endocr Relat Cancer, 2016 - erc.bioscientifica.com
… There are limited and inconsistent data in NET on molecular markers that have been
associated with response to checkpoint inhibitors such as PD-1 or PDL-1 staining in …

Neuroendocrine tumor biomarkers: current status and perspectives

IM Modlin, K Oberg, A Taylor, I Drozdov, L Bodei… - …, 2015 - karger.com
Novel requirements are necessary to develop … of multiple molecular markers and predictive
nomograms that interface biological variables to delineate disease progress or treatment

[HTML][HTML] Update on pancreatic neuroendocrine tumors

LR McKenna, BH Edil - Gland surgery, 2014 - ncbi.nlm.nih.gov
… PRRT is a novel therapy and investigations regarding its efficacy are ongoing. One series
of 504 patients with gastroenteropancreatic NETs treated with Lu-177 labeled PRRT reported …

The challenge of pancreatic cancer therapy and novel treatment strategy using engineered mesenchymal stem cells

MR Moniri, LJ Dai, GL Warnock - Cancer gene therapy, 2014 - nature.com
… in pancreatic cancer therapy, and we propose a novel strategy … anticancer genes to the site
of pancreas. We aim to provide a … and endocrine tumors can develop from different pancreatic

The dynamic interactions between the stroma, pancreatic stellate cells and pancreatic tumor development: Novel therapeutic targets

B Farran, GP Nagaraju - Cytokine & growth factor reviews, 2019 - Elsevier
… Hence, increased understanding of the interaction between tumor buds and the TME
could improve PC classification and guide the development of novel therapeutic strategies. …

Novel therapeutic approaches in GEP-NETs based on genetic and epigenetic alterations

J Pozas, T Alonso-Gordoa, M San Román… - … )-Reviews on Cancer, 2022 - Elsevier
Neuroendocrine tumors (NETs) are rare neoplasms arising from the neuroendocrine cells. …
Overview of the most relevant molecular pathways and targeted therapeutic strategies in NET …

Prognostic and predictive factors on overall survival and surgical outcomes in pancreatic neuroendocrine tumors: recent advances and controversies

L Lee, T Ito, RT Jensen - Expert review of anticancer therapy, 2019 - Taylor & Francis
… has become an increasing important novel therapeutic approach, therefore identifying useful
molecular markers to predict prognosis and therapeutic response is of increasing clinical …

Novel therapeutic strategies: Targeting epithelial–mesenchymal transition in colorectal cancer

N Zhang, AS Ng, S Cai, Q Li, L Yang, D Kerr - The lancet oncology, 2021 - thelancet.com
markers might serve as outcome predictors and potential therapeutic targets in colorectal
cancer. … summary of therapeutic compounds capable of targeting EMT markers, including drugs …

… tissue insulin-like growth factor-I receptor (IGF-IR) as a prognostic marker for prostate cancer and anti-IGF-IR agents as novel therapeutic strategy for refractory cases …

EE Ozkan - Molecular and cellular endocrinology, 2011 - Elsevier
molecular factors playing role on development of prostate carcinoma and novel treatment
strategies … interest over recent years as a novel therapeutic target in cancer. In this paper it is …

The selective PI3Kα inhibitor BYL719 as a novel therapeutic option for neuroendocrine tumors: Results from multiple cell line models

S Nölting, J Rentsch, H Freitag, K Detjen, F Briest… - PLoS …, 2017 - journals.plos.org
… Our results suggest that the agent BYL719 could be a novel therapeutic approach to the
treatment of NETs that may sensitize NET cells to somatostatin analogs, and that if there is …