Pancreatic neuroendocrine neoplasms: the latest surgical and medical treatment strategies based on the current World Health Organization classification

H Ishida, AKY Lam - Critical Reviews in Oncology/Hematology, 2020 - Elsevier
… There is a recent update in WHO classification of pancreatic neuroendocrine neoplasms (PanNENs).
Our aim is to analyse the latest management for patients with PanNENs according …

Molecular strategies and 111in-labelled somatostatin analogues in defining the management of neuroendocrine tumour disease: a new paradigm for surgical …

IM Modlin, M Kidd, T Hinoue, KD Lye, J Murren… - The Surgeon, 2003 - Elsevier
… genes that may be markers for human gastric carcinoid autonomy. These findings can then
… and novel therapeutic strategies in patients with ECL cell tumours. One of these molecular

A clinicopathologic and molecular update of pancreatic neuroendocrine neoplasms with a focus on the new World Health Organization classification

JM Fang, J Shi - Archives of pathology & laboratory …, 2019 - meridian.allenpress.com
… (PanNENs) include a new category of pancreatic neuroendocrine tumor, … pancreatic
neuroendocrine carcinoma. However, pancreatic neuroendocrine tumor grade 3 and pancreatic

[图书][B] Molecules to medicine with mTOR: translating critical pathways into novel therapeutic strategies

K Maiese - 2016 - books.google.com
… In light of the limited courses of action to treat many NCDs that currently have only
symptomatic or a handful of therapeutic options, development of novel therapeutic strategies to …

Functional roles of SRC signaling in pancreatic cancer: Recent insights provide novel therapeutic opportunities

AR Poh, M Ernst - Oncogene, 2023 - nature.com
… In this review, we discuss the molecular and immunological mechanisms by which aberrant
… , and discuss the clinical challenges associated with targeting SRC in pancreatic cancer. …

Insulinoma-associated protein 1 (INSM1): a potential biomarker and therapeutic target for neuroendocrine tumors

B Mahalakshmi, R Baskaran, M Shanmugavadivu… - Cellular Oncology, 2020 - Springer
… and use as a therapeutic target in various neuroendocrine tumors. Targeting signaling …
be instrumental for the design of novel therapeutic strategies for neuroendocrine tumors. …

Disruption of circulating extracellular vesicles as a novel therapeutic strategy against cancer metastasis

N Nishida-Aoki, N Tominaga, F Takeshita, H Sonoda… - Molecular Therapy, 2017 - cell.com
… the cancer microenvironment toward metastasis. Here, we provide a novel strategy for
therapeutic antibody treatment to target cancer-derived EVs and inhibit the metastasis of breast …

[HTML][HTML] Pancreatic neuroendocrine tumors: biology, diagnosis, and treatment

C Ro, W Chai, EY Victoria, R Yu - Chinese journal of cancer, 2013 - ncbi.nlm.nih.gov
Molecular markers that predict PNET behavior are necessary to improve clinical decision-making…
We provide an algorithm that summarizes the treatment strategies for PNETs (Figure 1). …

GSK3α/β: a novel therapeutic target for neuroendocrine tumors

ET Aristizabal Prada, C Weis, M Orth, M Lauseker… - …, 2018 - karger.com
… role of GSK3α/β in NETs and suggest that GSK3α/β inhibition could be a novel therapeutic
option in NETs, especially in combination with lovastatin or 5-FU, depending on tumor entity. …

NEN in a dish: A patient-derived organoid biobank illuminates potential novel therapeutic opportunities for neuroendocrine neoplasms

S Gerstberger, K Ganesh - Cancer Cell, 2023 - cell.com
Treatment … cell lung cancer (SCLC), the most common neuroendocrine cancer with $33,000
cases per year in the US,2 or are extrapolated from the treatment of epithelial cancers of the …