… progranulin deficiency because of a homozygous mutation in a … NCL caused by a homozygous
progranulin mutation segregating … Null mutations in progranulin cause ubiquitin-positive …

… Mutations in the progranulin gene (GRN) are a major cause of frontotemporal lobar degeneration
with ubiquitin-positive, tau-negative inclusions (FTLD-U) but the distinguishing clinical …

… mutations) is characterized by ubiquitin-positive intracytoplasmic and sometimes intranuclear
neuronal inclusions. The major … in FTLD-U with GRN mutations results in redistribution and …

… main components of the ubiquitin-positive inclusions typical of the GRN-mutated families, as
… Mutations in GRN do not lead to progranulin deposition in the brain but instead to an altered …

… Loss-of-function mutations in the progranulin gene were recently identified to cause tau-negative,
ubiquitin-positive frontotemporal dementia (FTD) (8, 9), the second most common …

… are linked to frontotemporal lobar degeneration with TDP-43 positive inclusions (FTLD-TDP-…
Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to …

… Moreover, deficiency of GRNs in frontotemporal dementia (FTD) caused by GRN mutations
may play a causal role in the development of lysosome dysfunction that underlies FTD-GRN, …

… Mutations in the progranulin (PGRN) gene were recently described as the cause of ubiquitin
positive frontotemporal … populations leading us to determine if these mutations were a major …

… , mutations in the progranulin gene (GRN) were reported to account for the vast majority of
Frontotemporal lobar Degeneration (… Two different pathogenic mutations causing progranulin …

… Null mutations in the progranulin gene (GRN, PGRN) were recently identified as the causal
mechanism underlying frontotemporal dementia (FTD) with ubiquitin-positive brain pathology …