… More recently, progranulin gene (GRN) mutations were recognized in association with …
main components of the ubiquitin-positive inclusions typical of the GRN-mutated families, as well …

… to the Leu271LeufsX10 PGRN mutation, we identified three novel progranulin mutations (c.709-…
Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to …

… major pathological protein of sporadic and familial frontotemporal lobar degeneration
with ubiquitin-positive… 17 was discovered as being mutations in the progranulin gene (PGRN).15, …

… of progranulin gene (GRN) mutations, which cause an … the form of parenchymal
ubiquitin-positive grains and dystrophic … structures in the region were ubiquitin-positive …

… (97) and the recently identified progranulin gene or PGRN on … whether mutations in the
TDP-43 gene can also cause FTLD-… it is caused by a PGRN mutation and that ubiquitin-positive …

… the familial tauopathy Frontotemporal dementia linked to chromosome 17 (FTDP-17). …
reports of mutations in PSEN1 and MAPT associated with cases of FTD with ubiquitin-positive tau-…

… Frontotemporal lobar degeneration (FTLD) is the most … FTLD have evidence of
ubiquitin-positive inclusions comprised of the … (GRN) gene is one of the major causes of …

… the clearly pathologic plasma progranulin levels, we decided to explore the molecular
mechanisms underlying this mutation. In … of ubiquitin-positive frontotemporal lobar degeneration …

… mutations are null mutations leading to haploinsufficieny. GRN is a microglial-expressed
gene and the progranulin … in atypical frontotemporal lobar degeneration with ubiquitin-positive …

… All cases with material available for immunohistochemistry had cytoplasmic and intranuclear
ubiquitin positive, tau negative inclusions that stained best with an antibody to the TDP43 …