… improved muscle pathology in a mouse model for Duchenne … in other muscular dystrophy
mouse models, such as different mouse models of the different types of limb-girdle muscular …

… mdx mouse model of Duchenne muscular dystrophy. mdx mice … In addition, three models
of limb-girdle muscular dystrophy, … that elimination of myostatin did not combat a laminin-2-…

… in histopathology but ultimately exacerbates muscle degeneration; … is a model for limb-girdle
type 2B and Miyoshi muscular … studies have shown that dysferlin is likely involved in Ca 2+ -…

… improved pathophysiology of the mdx mouse model of DMD. … limb girdle muscular dystrophies
(LGMDs) (6). Mutations in genes … 4), suggesting improvement of muscle pathology. We …

… - to 2-fold increase that we observed in the same muscles of … to test myostatin inhibition in
the mouse model for LGMD R1. In … histopathology suggesting that mechanisms involved in a …

… myostatin, that are involved in the negative regulation of skeletal … We tested the translational
hypothesis that blocking ligand … a significant 16% increase in body weight after 2 weeks (four …

… of DMD (mdx), limb girdle muscular dystrophy 2F (Sgcg-/-), and … Myostatin blockade did not
attenuate the pathology in a … IIB receptor improves function in a mouse model of amyotrophic …

… is necessary for activation of its protein function [2]. … in clinical development for limb
girdle muscular dystrophy, a … muscle strength and the pathology of patients with muscular …

… models suggested that it aggravated the primary pathology. … mouse models which either lack
or over-express Myostatin. In … of the rare limb girdle muscular dystrophy type 2G (LGMD 2G) …

… histopathology. The same beneficial effects were obtained in mice models of LGMD2C and
E, following direct muscle … caveolaes in LGMD1C could stimulate myostatin signalling and …