… Studies of muscle pathology in severe SMA patients and mice … of limb-girdle muscular
dystrophy mouse models due to loss … 2 B), but due to mouse variability this did not reach statistical …

… Myostatin blockade improves function but not histopathology in a murine model of limb-girdle
muscular dystrophy 2C … mediated myostatin blockade led to increased fiber size, muscle …

… Among the 25 forms of LGMD, the 17 disorders classified as type 2 are recessive … that
counteracts the effect of myostatin in suppressing muscle growth, has potential to increase muscle …

… We also found no effect of myostatin on satellite cell behavior in vitro. … Myostatin blockade
improves function but not histopathology in a murine model of limbgirdle muscular dystrophy 2c…

… is whether myostatin inhibition can improve function of the … that Studies 1 and 2 were
undertaken separately and did not … inhibition of myostatin in muscular dystrophy. Because in many …

… manifests as a more severe pathology, which limits functionality… Limb Girdle Muscular
Dystrophy R1 mouse model (C3KO) … However, improved functional testing was not observed in …

… of myostatin induces skeletal muscle atrophy [2]. A multitude … mdx mouse model of Duchenne
muscular dystrophy leads to … KO diaphragm demonstrates improved histopathology at a …

… myostatin inhibition attenuated the skeletal muscle atrophy and loss of muscle force-producing
capacity in a murine model … study (33); and 2) calcineurin signaling induces a slow …

… -myostatin approaches, we used the Mtm1-KO mouse model. … the myostatin pro-peptide
D76A mutant (PropD76A) and 2 … , muscle histology was greatly improved with an increase of …

… dystrophy, inclusion body myositis, limb-girdle muscular … exceeded that of untreated wild-type
mice (Figure 2B). We did … -automatic muscle analysis with the segmentation of histology (…