… , and myostatin is linked to various features of muscle pathology, … will elaborate on findings
in Duchenne and limb-girdle MDs. … breeding myostatin-null mice to several mouse models of …

… in animal models of two limb-girdle muscular dystrophies: … growth, we assessed its
beneficial effect on pathology in α-… in a mouse model of limb-girdle muscular dystrophy type 2A. …

… We previously developed a mouse model of DMD that … that the combination of targeting
TGFβs and myostatin due to … and sarcoglycan-mediated limb girdle muscular dystrophy (LGMD) …

… inhibitor of myostatin, designed to increase muscle mass and … In the mdx mouse model
of muscular dystrophy, animals … (FSHD), and limb-girdle muscular dystrophy (LGMD). A …

… limb-girdle and congenital muscular dystrophies, and myotonic … α-dystroglycan glycosylation
in the mouse model and human cells.[… that myostatin blockade benefits a dystrophic heart. …

… The murine models are useful in verification experiments for … the histopathological lesions
are localized in the limb-girdle … to myostatin, MYO-029, has been conducted in adult muscular …

… Limb-girdle muscular dystrophies (LGMDs) are a group of … In two mouse models of
sarcoglycanopathy, post-natal inhibition of myostatin increased muscle mass [29, 30] and improved …

… ), a mouse model for limb girdle muscular dystrophy 2D. Galgt2 … a similar weight of muscle
with SDS/urea buffer (2% SDS, 4 … mdx mice but not in dy/dy mice,18, 86 myostatin inhibition is …

… −/− model of limb-girdle muscular dystrophy 2F (LGMD2F). … The role of myostatin in
pathogenesis of muscular dystrophy … be beneficial in mouse models, it did not restore full function. …

… the activin receptor ActRIIB and Smads 2 and 3. Approaches … -deficient mouse model of
limb-girdle muscular dystrophy 1C… model, does not improve all aspects of muscle pathology; this …