NLRX1 attenuates apoptosis and inflammatory responses in myocardial ischemia by inhibiting MAVS-dependent NLRP3 inflammasome activation

H Li, S Zhang, F Li, L Qin - Molecular Immunology, 2016 - Elsevier
… recently been identified as key mediators of inflammatory responses. The aim of this study …
mechanism of NLRX1 in myocardial ischemic injury. The results show that NLRX1, located in …

NLRX1 alleviates lipopolysaccharide-induced apoptosis and inflammation in chondrocytes by suppressing the activation of NF-κB signaling

D Ma, Y Zhao, J She, Y Zhu, Y Zhao, L Liu… - International …, 2019 - Elsevier
… significantly improved cell viability and attenuated LPS-treated chondrocyte apoptosis and
… , NLRX1 overexpression alleviates myocardial ischemia-induced inflammatory responses

[HTML][HTML] NLRX1 deletion increases ischemia-reperfusion damage and activates glucose metabolism in mouse heart

H Zhang, Y Xiao, R Nederlof, D Bakker… - Frontiers in …, 2020 - frontiersin.org
… that NLRX1 reduces apoptosis and inflammatory responsesNLRX1 is known to function
as a negative NLR, attenuating … effects on cytokines were mediated through inhibition of …

NLRX1 knockout aggravates lipopolysaccharide (LPS)-induced heart injury and attenuates the anti-LPS cardioprotective effect of CYP2J2/11, 12-EET by enhancing …

G Zhao, X Wang, S Edwards, M Dai, J Li, L Wu… - European Journal of …, 2020 - Elsevier
… , and attenuated the inhibitoryNLRX1 to weaken inflammatory responses induced by
LPS or viral infection on immune cells, and attenuate the inflammation in myocardial infarction

[HTML][HTML] Inhibition of microRNA-15 protects H9c2 cells against CVB3-induced myocardial injury by targeting NLRX1 to regulate the NLRP3 inflammasome

R Tong, T Jia, R Shi, F Yan - Cellular & Molecular Biology Letters, 2020 - Springer
inflammatory responses are mediated by NLRX1, we co-transfected si-NLRX1 or si-NC with
miR-15 inhibitor … increased cell apoptosis were found in the miR-15 inhibitor+si-NLRX1 + …

Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury

S Toldo, AG Mauro, Z Cutter… - American Journal of …, 2018 - journals.physiology.org
inflammatory response during AMI. In an in vitro model of hypoxia-induced myocardial injury,
NLRX1 has been found to inhibit … MI, inhibited expansion of LV scar size at 1 wk, attenuated

NLRP3 inflammasome in acute myocardial infarction

AG Mauro, A Bonaventura, E Mezzaroma… - Journal of …, 2019 - journals.lww.com
… molecular patterns and amplifies the inflammatory response and cell death through caspase-1
… -induced myocardial injury, the NLR family member X1 (NLRX1) has been found to inhibit

NLRX1 increases human retinal pigment epithelial autophagy and reduces H2O2-induced oxidative stress and inflammation by suppressing FUNDC1 …

Q Wang, F He, L Wu - Allergologia et immunopathologia, 2023 - all-imm.com
… immune system function which inhibits inflammatory response, attenuates reactive oxygen …
NLRX1 attenuates apoptosis and inflammatory responses in myocardial ischemia by inhibit

[HTML][HTML] Daming capsule protects against myocardial infarction by promoting mitophagy via the SIRT1/AMPK signaling pathway

X Sun, Y Han, C Dong, H Qu, Y Yu, J Ju, Y Bai… - Biomedicine & …, 2022 - Elsevier
NLRX1 expression, leading to structural damage and functional impairment in mitochondria,
as well as increased oxidative stress, inflammatory response, … DMC attenuates myocardial

TAX1BP1 protects against myocardial infarction-associated cardiac anomalies through inhibition of inflammasomes in a RNF34/MAVS/NLRP3-dependent manner

H Xu, W Yu, S Sun, C Li, J Ren, Y Zhang - Science Bulletin, 2021 - Elsevier
… detrimental consequences of the inflammatory response [14], … to assess myocardial apoptosis
using an in-situ cell death … TAX1BP1 significantly attenuated myocardial ischemic injury …