[HTML][HTML] MiR-423-5p regulates cells apoptosis and extracellular matrix degradation via nucleotide-binding, leucine-rich repeat containing X1 (NLRX1) in interleukin 1 …

H Xu, L Ji, C Yu, Q Chen, Q Ge, Y Lu - Medical Science Monitor …, 2020 - ncbi.nlm.nih.gov
… Besides, luciferase activities were significantly decreased when … of NLRX1 depletion leading
to apoptosis have been shown to be mitochondrial impairment and excess oxidative stress […

Mitochondria as molecular platforms integrating multiple innate immune signalings

M Monlun, C Hyernard, P Blanco, L Lartigue… - Journal of molecular …, 2017 - Elsevier
… , mitochondria are crucial executioners of the apoptotic cell … Mitochondrial components
including gC1qR and NLRX1 can … of the generated mitochondrial oxidative stress on NLRP3 …

[HTML][HTML] NLRX1 Prevents M2 Macrophage Polarization and Excessive Renal Fibrosis in Chronic Obstructive Nephropathy

Y Liu, L Kors, LM Butter, G Stokman, N Claessen… - Cells, 2023 - mdpi.com
… hepatocytes and renal tubular cells, during cell stress and tissue injury [25,26]. To … NLRX1
dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity

[PDF][PDF] Role of Mitochondrial Oxidative Stress in the Pathophysiological Mechanisms of Epilepsy

N Cárdenas-Rodríguez - downloads.hindawi.com
… in epithelial cells during ischemia-reperfusion injury [53]. It indicates the … of NLRX1 in the
control of mitochondrial activity and prevention of oxidative stress and apoptosis in tissue injury, …

[HTML][HTML] Inflammasome-independent role of NLRP3 mediates mitochondrial regulation in renal injury

SM Kim, YG Kim, DJ Kim, SH Park, KH Jeong… - Frontiers in …, 2018 - frontiersin.org
… the release of mitochondrial pro-apoptotic and apoptotic molecules. … used to measure the
levels of the oxidative stress marker 8-OHdG (… and dampen additional damages. Previous UUO …

[HTML][HTML] NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity

M Gharagozloo, S Mahmoud, C Simard… - PLoS …, 2019 - journals.plos.org
… , including oxidative damage, mitochondrial dynamics, and … in neurotoxic glia and exacerbated
tissue injury in Nlrx1 −/− 2D2 … was done with Annexin V Apoptosis Detection Kit per the …

Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases

CSD Cruz, MJ Kang - Mitochondrion, 2018 - Elsevier
mitochondrial activities that include oxidative phosphorylation for cell growth and survival,
suppression of mitochondria-mediated apoptosis … or dampening the excessive oxidative stress

[HTML][HTML] Nlrx1-Regulated Defense and Metabolic Responses to Aspergillus fumigatus Are Morphotype and Cell Type Specific

B Kastelberg, T Ayubi, N Tubau-Juni, A Leber… - Frontiers in …, 2021 - frontiersin.org
… if Nlrx1 regulated the production of general oxidative stress (… of basal mitochondria function
results in a Nlrx1-independent … consumption, oxidative stress, and downstream apoptosis (…

[HTML][HTML] Pathological and therapeutic advances in Parkinson's disease: mitochondria in the interplay

P Naren, A Cholkar, S Kamble, SS Khan… - Journal of …, 2023 - content.iospress.com
… to oxidative damage leading to its dysregulated function. … its dampened concentration may
contribute to an excess of … that ameliorate inflammation, oxidative stress, and apoptosis, which …

Multi-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication

H Guo, QI Wang, K Ghneim, LI Wang… - Nature …, 2021 - nature.com
… and tryptophan and elevated oxidative stress in immune cells 4 . … that mitochondria-localized
innate immune protein NLRX1 and … either NLRX1 or FASTKD5 in CD4 + T cells dampened