… the apoptotic machinery at the level of the ancestral mitochondria, has … of NLRX1 (member
of the Nod-like receptor family) to … Mitochondria dysfunction and oxidative stress are mediators …

… For example, the innate immune receptor NLRX1, a member … suggests that oxidative stress
and mitochondrial injury can … the role of the mitochondria in apoptotic cell death processes …

… , we discovered that NLRX1 is protective against disease burden when NLRX1 is … NLRX1
dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity…

… if Nlrx1 regulated the production of general oxidative stress (… of basal mitochondria function
results in a Nlrx1-independent … consumption, oxidative stress, and downstream apoptosis (…

… NLRX1 activity is also dependent on mitochondrial function. However, it is currently known
that NLRX1 … 1; vMIA, viral mitochondrial-localized inhibitor of apoptosis. Note: Other viruses …

… CPT induces death of A549 cells via characteristic of apoptosis … demonstrate that NLRX1
dampens the oxidative stress [27]. … NLRX1, we identified the p53 RE within its promoter using …

… We also assess the recent advances in targeting mitochondrial dysfunction including …
NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity…

… Moreover, mitophagy retards mitochondrial apoptosis via … fission and oxidative stress.
These findings support the … activates NLRX1 in macrophages, NLRX1 translocates to MOM via …

… their non-canonical activity. Here we show that … NLRX1 dampens oxidative stress and
apoptosis in tissue injury via control of mitochondrial activity. J Exp Med. 2017; 214 (8): 2405-20. …