… with GLPG1690 ameliorates hyperoxia-induced LOX expression in … Moreover, the enzyme,
sphingosine kinase 1 (SPHK1) was … Neonatal therapy with PF543, a sphingosine kinase 1 …

… a role for sphingosine kinase (SphK)1, but not SphK2, in … We next evaluated the effect of
PF543 on hyperoxia-induced p47 … in the lung could serve as a potential therapy to ameliorate …

… kinase (SPHK) is implicated in acute immunoresponses, however, … of bronchial asthma are
poorly understood. In this study, we hypothesized that SPHK inhibition could ameliorate lung …

… be a therapeutic approach in ameliorating experimental PF … , is phosphorylated by sphingosine
kinase (SPHK) 1 or 2 to … with PF543 (a specific inhibitor of SPHK1) reduced bleomycin…

… Of the two closely related sphingosine kinases (SphKs)1 and … effect of PF543 on
hyperoxia-induced p47phox translocation … as a potential 352 therapy to ameliorate BPD and …

… Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-induced
airway remodeling in a murine model of bronchopulmonary dysplasia[J]. Am J Physiol …

… Inhibition of SPHK1 by the inhibitor, PF543, also decreased … and U251-MG SPHK1 orthotopic
mouse models. In summary, … PF543 is effective in mitigating bronchopulmonary dysplasia …

… Airway remodeling is a cardinal feature of severe asthma. These results demonstrate that …
-driven airway remodeling can be inhibited by FTY720, offering potential new therapies for the …

… or inhibition resulted in amelioration of PA-induced lung … ) were subjected to sphingosine
kinase activity assay in Hepes … containing a SphK1 inhibitor, PF543 (1 µM), or SphK2 inhibitor, …

… In recent years, sphingosine kinase 1 (SphK1) has been … At present, PF-543 is the most
widely used SphK1 inhibitor, … Studies in a mouse model of IBD found that LCL351 reduced …