… While CD8+ T-cell-mediated immune suppression is similar between healthy … deficient
during acute exacerbation of MS. Of note, the recovery of neuroantigen-specific CD8+ T-cell …

… neuroantigen-specific CD8 + Tregs were harbored in a unique CD8 + T cell subset, and that
a deficit in that … underlies the impaired CD8 + Treg suppressive ability during acute disease …

… its role in CD8 + T cell-mediated neuroantigen-specific … immune regulatory function of
neuroantigen-specific CD8+ T … deficit in CD4+ and CD8+ T cell regulatory function underlies …

… , we have shown that neuroantigen-specific CD8 + Tregs can … direct evidence for CD8 + T-cell
regulatory function in MS and … of the neuroantigen-specific CD8 + suppressor deficit would …

… -established murine model of multiple sclerosis, an immune-… least in part through modulation
of CNS-specific CD4+ T cell … MOG-CD8+ could inhibit disease in an IL-10-deficient setting. …

… detect any associations with clinical exacerbations (77, 78). … -specific T-cell lines isolated
from MS patients during acute … yet if the regulatory function of B cells might be defective in MS. …

… in augmentation of demyelination and worsening of EAE 32, … deficiency was even more
pronounced on CD8 + T cell population. Additionally, absolute numbers of both CD4 + and CD8 …

… CD8 + T-cell responses Several studies have demonstrated the presence of neuroantigen-specific
T-cell … by interferon-gamma and is defective in chronic progressive multiple sclerosis. …

… Hence, MHC I deficiency or CD8 T cell blockade protects … these regulatory CD8 T cells is
lower during MS exacerbations … with irradiated neuroantigen-specific CD4 T cell clones, lyse …

… class I and that neuroantigen-specific CD8 + T cells infiltrate … The concept of anti-neuronal
CD8 + T cell–initiated gray matter … the pathogenic role of neuronal antigen–specific CD8 + T …