Nitrates and NO-NSAIDs in cancer chemoprevention and therapy: in vitro evidence querying the NO donor functionality

T Dunlap, SO Abdul-Hay, REP Chandrasena… - Nitric Oxide, 2008 - Elsevier
… of its benzyl nitrate metabolite NCX 4015… vitro data are presented on GT-094, NO-ASA, and
control compounds conisogenic with NO-ASA, which do not contain a NO-donating or nitrate

Anti-inflammatory, antiproliferative, and cytoprotective activity of NO chimera nitrates of use in cancer chemoprevention

GK Hagos, SO Abdul-Hay, J Sohn, PD Edirisinghe… - Molecular …, 2008 - ASPET
nitrates in vitro was equivocal, and combinations of nitrates … of the use of nitric oxide donor
NSAIDs (NO-NSAIDs) in CRC … inherently are not compatible with oxidizable functional groups …

Nitric Oxide-Releasing Molecules for Cancer Therapy and Chemoprevention

S Anand, GRJ Thatcher - … Oxide (NO) and Cancer: Prognosis, Prevention …, 2010 - Springer
… of NO donors with potential utility in cancer chemotherapy and … NO-NSAIDs were conceived
as prodrugs to utilize NO … even before the physiological functions of NO were realized and …

[HTML][HTML] Nitric oxide (NO) and NO synthases (NOS)-based targeted therapy for colon cancer

H Wang, L Wang, Z Xie, S Zhou, Y Li, Y Zhou, M Sun - Cancers, 2020 - mdpi.com
NO-donating NSAIDs (NO-NSAIDs) possess a traditional … modulate the NO-releasing rate
and targeting capability of NO-… has the risk of the rapid bursting of toxic agents, such as nitrates

Nitrates and NO release: contemporary aspects in biological and medicinal chemistry

GRJ Thatcher, AC Nicolescu, BM Bennett… - Free Radical Biology and …, 2004 - Elsevier
nitrates, including NO-NSAIDs, do not behave as NO donors … nicorandil represent nitrates
containing functionalities, other … In reviewing NO-NSAIDs in colon cancer chemoprevention, …

Nitroxyl (HNO): a possible strategy for fighting cancer

ME Shoman, OM Aly - Current Topics in Medicinal Chemistry, 2016 - ingentaconnect.com
… Critical thiols that control cancer cellular functions might be … the heme-iron-catalyzed reduction
of nitrite with H2S [11]. This … -NSAIDs) is one important strategy to minimize NSAIDs side …

The latest advances in the discovery of nitric oxide hybrid drug compounds

RAM Serafim, FG Pernichelle… - Expert Opinion on Drug …, 2017 - Taylor & Francis
… , ester nitrate and S-nitrosothiol are the main functional groups … This study showed that this
new NSAIDs/NO-donor hybrid has … , the treatment in vivo with complex non-bound NO did not

[HTML][HTML] Reconsidering the role of cyclooxygenase inhibition in the chemotherapeutic value of NO-releasing aspirins for lung cancer

A Martin-Martin, A Rivera-Dictter, M Muñoz-Uribe… - Molecules, 2019 - mdpi.com
… -aspirins has been queried. Moreover, different isomers exhibit … , NO-NSAIDs may also
have roles in cancer treatment or … both in vivo and in vitro models of leukemia, ovarian cancer, …

Nitric oxide and cancer therapy: the emperor has NO clothes

JR Hickok, DD Thomas - Current pharmaceutical design, 2010 - ingentaconnect.com
… In addition to the many normal physiologic functions of NO·, it … shows promise for colorectal
cancer chemoprevention due to its … Nitrates and NO-NSAIDs in cancer chemoprevention and …

for Nitric Oxide Mission

S Mijatovic, D Maksimovic-Ivanic… - Nitric Oxide (NO) …, 2010 - books.google.com
Nitrates and NO-NSAIDs in cancer chemoprevention and therapy: in vitro evidence querying
the NO donor functionality. Nitric Oxide 19, 115–124. Fiers, W., Beyaert, R., Declercq, W., …