… Here we discuss two novel RING E3 ligases, BCA2 and RNF11, that are closely linked to
human breast cancer. BCA2 E3 ligase is coregulated with estrogen receptor and plays a role in …

… we examined whether the breast cancer-associated gene 2 (BCA2), a novel RING domain
protein, has E3 ubiquitin ligase activity and investigated its expression status in breast tumors. …

… in human breast cancer [127]. On the contrary, another study on breast cancer indicated that
… of breast cancer cells by TGF-β/Smad-mediated epithelial-mesenchymal transition (EMT) […

… specific RING E3 ligases could lead to the development of a novel class of … ubiquitin ligase
activity of the RING-domain mutations is being used as a prognostic marker for breast cancer. …

… Our study suggests a novel non-genomic mechanism of ER stability control (see model Figure
8c). On the basis of these data we propose that selective modulation of RNF31 expression …

… breast cancer cells (p53+/+ with Hdm2 overexpression) as well as into MCF10A immortalized
breast … therapy of human prostate cancer by inhibiting MDM2 expression with novel mixed-…

… the E3 ubiquitin ligase TRIM56 as the novel modulator of ER alpha signaling in breast cancer…
Here we report that the RING family ubiquitin ligase TRIM56 associates with and stabilizes …

… presence of either a HECT or a RING domain. RING ubiquitin ligases, which are the focus of
this … -conjugating enzymes and promotes a direct transfer of ubiquitin to substrate by a novel …

… Now known as RNF11, the gene encodes a RING-H2 domain … , an E3 ubiquitin ligase that
mediates the ubiquitination and … genes involved in breast tumours will yield novel targets for …

… BCA2 is an E3 ubiquitin ligase that was isolated from an invasive breast … In this paper, we
describe the synthesis and antitumor evaluation of four series of novel “zinc-affinic” agents, in …