… We hypothesized that an increasing neural respiratory drive (NRD) is associated with the
severity of sleep-disordered breathing at altitude. Methods: Mountaineers were studied at sea …

… by waking neural drive [8] and resultant apnea when this drive is lost during sleep. The PCO2
… Small observational studies revealed that trekkers in Nepal (5050m above sea level) with …

… Based on observational studies, many of them performed in … in sleep structure at altitude
consisted in a reduction of deep … and possibly sleep disturbances in causing central nervous …

… instability and thus central sleep apnea. Thus the second … autoregulation would be lowered
during sleep at high altitude. … This observation offers rationale for further studies on the …

… being a part of a large mass of nervous tissue with relatively low perfusion, unlike carotid
body. … breathing with apnea according to our observation presented in fig. 10. A decreased …

… with increasing altitude may explain the observation of worsening sleep with increasing …
The cost to the central nervous system of climbing to extremely high altitude. N Engl J Med …

… to moderate/high altitudes is the central sleep apnea syndrome,[6] but exposure to … from
observational and intervention studies regarding the effects of altitude on breathing during sleep …

… breathing experienced at high altitude exacerbates sleep fragmentation, with recent evidence
that hypoxia is the most important factor,28 but our study … SpO 2 decreased at high altitude, …

… of both the hypoxic and hypercapnic ventilatory responses in normal volunteers in the transition
between low altitude and high altitude [2]. They confirm a similar observation by White et …

… This suggestion is based on the observation that hypoventilation is a physiological feature
… during sleep in polycythemia of high altitude: improvement with respiratory stimulation. …