… Finally, we assessed the ability of BiTEs to activate T‐cell cytotoxicity to SKOV3 target cells
in the presence of immunosuppressive ascites or pleural fluid following infection with EnAd‐…

… along with the T cell-mediated cytotoxicity of CAFs were … target cancer cells through
virus-mediated oncolysis and to re-… the genome of the oncolytic adenovirus ICO15K to express a …

… less cytotoxic to non-cancer cells but increase their ability to … The replication of oncolytic
adenovirus in tumor cells is strictly … T cells in liquid cancer biopsy samples without additional …

… a new class of antibodies that re-direct T-cells to cancer cells, … that another oncolytic adenovirus
expressing a chimeric BiTE … T-cell activation, proliferation, and cell-mediated cytotoxicity …

… oncolytic adenovirus that encodes a bispecific antibody … A, Cytotoxicity in T-cell and NHDF
cocultures was assessed … tumor biopsies with EnAd-FAP-BiTE led to tumor-associated T-cell …

… supported bystander cell-mediated cytotoxicity. In two distinct … Indeed, treatment of fresh
clinical biopsies, including … This FBiTE was inserted in the oncolytic adenovirus ICOVIR15K …

… The goal of this review is to provide an introduction into the … T cells to cancer cells are
bispecific T-cell engagers (BiTEs) [… T-cell cytotoxicity against M2-TAMs in cancer patient biopsies, …

… On-target off-tumor toxicity as a safety concern of redirecting … slices derived from prostate
cancer biopsies. Following virus … an oncolytic adenovirus encoding a FAP-TAc (T cell activator…

… engager (BiTE) binds to a selected antigen on target cells and … This strategy can potentiate
the cytotoxicity of EnAd and we … using BiTEexpressing oncolytic adenoviruses (chapter five). 4…

… Bispecific T cell engagers are a promising class of therapeutic proteins for cancer therapy.
Their potency and small size often come with systemic toxicity and short half-life, making …