… the T cell triggers a targeted release of cytotoxic granules into … -T cells and target them to
pancreatic cancer cells in order to … late, research into liquid biopsies and molecular diagnostics …

… primary T cell activation and T cell-mediated cytotoxicity … Fajardo et al. engineered an
oncolytic adenovirus, ICOVIR-… the efficacy of OV-BiTE in cancer biopsies. However, the lack of a …

… cancer (OC) is related to the action of infiltrating cytotoxic T … In this study, we tested the
hypothesis that bispecific T-cell … in the biopsy of all tested patients tested positive for PD1 …

… T-cell-engaging bispecific antibodies (bsAbs) are emerging as a … in xenograft models and
an oncolytic adenovirus encoding a CD3-… So-called “on-target, off-tumor toxicity” might limit the …

… ) presentation, T-cell proliferation, activation, and cytotoxicity against … presentation across
multiple biopsies. This observation … oncolytic adenovirus, EnAd, to express TAM-targeting T cell …

… an oncolytic vaccinia virus with a secretory bispecific T-cell … the signature NK and T cell
activation and cytotoxic genes by … risk of potential on-target off-tumor toxicity. Delivery of BiCEP …

… The 24-bp deletion present in some oncolytic adenovirus … is the ultimate goal of Ad gene
therapies for cancer. However… required to activate T cell function via the T cell receptor (TCR). (D…

… toxicity at the lowest dose of 0.2 × 10 9 T cells infused, with subsequent examination of patients'
liver biopsies revealing CAIX expression … ” oncolytic adenoviruses targeting both cancer …

… that oncolytic measles viruses encoding bispecific T-cell … local BiTE-mediated cytotoxicity
and oncolytic immune modulation would … , target-specific T-cell activation and induction of T-cell …

… adenovirus-specific memory CD4+ and cytotoxic CD8+ T cell (CTL) responses. Conserved
epitopes within the adenovirus capsid (mostly hexon) are the main targets for … tumor biopsies …