… tumor cells, and selectively direct T cytotoxicity to tumor cells. … microenvironment in fresh
clinical biopsies 77 … , Fisher KD et al: Oncolytic adenovirus expressing bispecific antibody targets …

… in a more rapid T cell activation and target cell killing by virus-… virus, and BiTE-mediated T
cell cytotoxicity. This result is in so far … an oncolytic NDV encoding an anti-CD28 scFv as T cell …

… , treatment with an oncolytic adenovirus was associated with … T cell responses, whereas
PD1 blockade induced only a … (IHC) staining of paired biopsies from evaluable patients with …

… -target … expression of bispecific (CD3 and TAA) T cell engager (BiTE) molecules from OVs.
These BiTE molecules can drive activation of cytotoxic T cells by generating an artificial, T cell …

… ways: both target a surface TAA, both exploit T-cell effector … Fajardo et al. described an
oncolytic adenovirus encoding … landscape of the tumor from a biopsy guides the selection of the …

… replication and cytotoxicity of GD116 in breast cancer cells in … size reductions and CD8-positive
T cell infiltration that was … biopsies of a human breast cancer tumor, reovirus treatment …

… overcome critical barriers in the T cell journey, leading to … mice showed that oncolytic
adenovirus improved the activity of … activate T cells in tissue biopsy samples. A related strategy is …

… (VEGF-A) enhances oncolytic VV cytotoxicity by studying the effect of … This anti-CD47 oncolytic
adenovirus could induce durable … with T-cell retargeting bsAb, also called Bispecific T-cell …

… to redirect cytotoxic T cells to predefined tumour targets, … This Review focuses on T cell-redirecting
bispecific antibodies, … -bearing mice with an oncolytic adenoviral vector encoding an …

… cells in the TME that hamper T-cell priming/activation (5). Failure to … generates neutralizing
antibodies, which target infected cells for … This avoids systemic toxicity and reduces the cost of …