… lyse cancer cells through a mechanism known as ‘oncolysis’ or indirectly target cancer cells
… In the latter case, multiple effector/cytotoxic activities of both the innate and adaptive arms of …

… focus on direct T-cell activation as a target for cellular … ), and post-treatment tumor biopsy
demonstrated infiltration by P-… BiTE-expressing oncolytic adenoviruses with CAR T-cell therapy …

… to create cancer selectivity of oncolytic adenoviruses. Small … Repetitive biopsies from patients
treated with GL-ONC1 … , insertion of single-chain T-cell receptors, and modifications on the …

… Center from a single fineneedle biopsy [14] conform the … the incorporation of a bispecific
T-cell engager directed at FAP [… Finally, we addressed whether the superior cytotoxicity of …

… this or any other protocol involving human biopsies. … Oncolytic Adenovirus Here, we describe
an experiment using an EpCAM-targeted bispecific T cell engager delivered by an oncolytic …

… An oncolytic adenovirus (MEM-288) expressing MEM40 + … to the TME without causing
systemic toxicity. Herein, we report … Genomic DNA of biopsy tissue or PBMCs was isolated using …

… for the sensitivity to oncolytic adenovirus therapy alone or in … HER2 derived from
patient biopsies were cultured in Matrigel … the CAR T cell by a bystander effect of CAR T-cell–derived …

… , oncolytic adenoviruses expressing bispecific T cell engagers have shown to effectively target
… This includes the use of anti-cytotoxic T cell lymphocyte antigen 4 (CTLA4) antibodies and …

… has potent and tumor-selective cytotoxicity, inducing a non-… who had abdominal wall
metastases biopsied 39 days after the … One example is the expression of a bispecific T-cell …