[PDF][PDF] Perforin Lytic Activity Is Controlled by

D Hudig, SA Fraser, R Karimi, M Michalak - J Immunol, 2000 - Citeseer
cytotoxic lymphocyte granules are responsible for a significant fraction of T and NK cell-mediated
death. Perforin is stored in these granules … the increase in specific gravity of granules

Calreticulin, a component of the endoplasmic reticulum and of cytotoxic lymphocyte granules, regulates perforin-mediated lysis in the hemolytic model system

SA Fraser, M Michalak, WH Welch… - Biochemistry and cell …, 1998 - cdnsciencepub.com
molecule that protects cytotoxic lymphocytes from their own … Perforin enhancing protein
(PEPr), a low molecular weight protein of cytotoxic lymphocyte granules, enhances perforin