… As a result of this study, vinflunine was the first drug to receive approval from the European
… TCCU patients. We conducted a retrospective, observational, and non interventional study (…

… Vinflunine ditartrate is a microtubule … This phase I study was carried out to evaluate the
maximal tolerated dose, the safety profile, the pharmacokinetics and the activity of oral vinflunine (…

… patients receiving first-line treatment for metastatic breast cancer were recruited to a phase
I study of vinflunine … Results of a phase II and pharmacokinetic study in patients progressing …

… In this phase II trial, we evaluated the efficacy of vinflunine as first-line treatment in patients
with … Results of a phase II and pharmacokinetic study in patients progressing after first-line …

… the risk of accumulation in patients with renal or liver impairment. … Pharmacokinetic analyses
showed that capecitabine had no significant impact on the pharmacokinetics of vinflunine…

… In this study, 29% of mUC pts had liver metastasis, and most had prior treatment with a CPI
(79%), … Safety/tolerability and pharmacokinetics of PT2977 in this trial will also be evaluated. …

… Vinflunine has also been assessed in a Phase II study for treatment of patients with bladder
cancer … Results of a Phase II and pharmacokinetic study in patients progressing after first-line …

… Malignant pleural mesothelioma (MPM) is a disease of increasing incidence for which
treatment options are limited. This study reports the clinical efficacy data for vinflunine, a novel …

… In the combination arm, patients received iv vinflunine 280 mg/m 2 on day 1 plus oral …
of advanced breast cancer. Results of a phase II and pharmacokinetic study in patients …

… phase II study was aimed at exploring the feasibility as well as clinical efficacy and tolerability
profiles of two vinflunine combinations in UC patients. … study was to determine the disease …