… between gefitinib and irinotecan [18–21]. We therefore conducted a phase I study combining
gefitinib with bolus 5-fluorouracil (5-FU), irinotecan, and leucovorin (IFL) in patients with …

… of irinotecan or oxaliplatin with 5-fluorouracil … phase I study using this regimen as well as a
phase II study with this regimen in previously treated patients with metastatic colorectal cancer …

… irinotecan, dose reduction was required. We propose that the interaction of irinotecan and
gefitinib in our trial … in greater than anticipated exposure to irinotecan and its active metabolite. …

… Phase I study of FOLFOX plus gefitinib because of the high frequency of EGFR expression
in colorectal cancers … to combine this agent with oxaliplatin rather than irinotecan [4, 15]. This …

… BI: Phase II study of gefitinib, fluorouracil, leucovorin, and … previously treated patients
with metastatic colorectal cancer. … and leucovorin: an active regimen for first-line metastatic …

… In this study, the DLTs of irinotecan and gefitinib in combination were diarrhoea and
neutropenia… When irinotecan, infused 5-FU and leucovorin (FOLFIRI) was combined with erlotinib …

… of phase I and II studies in metastatic colorectal carcinoma … effects of gefitinib in combination
with standard 5-fluorouracil (5-… a recent study combining gefitinib and irinotecan in patients …

… L, Haller DG, O’Dwyer PD: A phase II trial of gefitinib with 5-fluorouracil, leucovorin, and
irinotecan in patients with colorectal cancer. Br J Cancer 2005;92:1846–1849. 12 Rothenberg M, …

… colorectal cancer. A response rate of 78% has been reported in a phase II study combining
gefitinib with … when combined with irinotecan in patients with irotecan-resistant colorectal …

… kinase inhibitors, like gefitinib, that are … study, a phase III program has been started that
investigates the addition of cetuximab to irinotecan plus infusional 5-FU/FA (ie CRYSTAL study…