RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients
JC Heinrich, A Tuukkanen, M Schroeder… - Journal of cancer …, 2011 - Springer
… When we tested RP101 as an anti-cancer drug in a rat model… , DNA repair, and recombination.
It regulates apoptosis through … “recovery” treatment in the phase 2 study: In this study, one …
It regulates apoptosis through … “recovery” treatment in the phase 2 study: In this study, one …
Redefining the role of interferon in the treatment of malignant diseases
S Bracarda, AMM Eggermont, J Samuelsson - European Journal of Cancer, 2010 - Elsevier
… These features make it a rational anticancer therapy; … and antiviral activity, whereas type II
IFN-γ has weaker antiviral … Two phase II studies have demonstrated that although sorafenib (…
IFN-γ has weaker antiviral … Two phase II studies have demonstrated that although sorafenib (…
Guanylyl Cyclase C Vaccines for Secondary Prevention of Metastatic Colorectal Cancer
JC Flickinger Jr - 2023 - search.proquest.com
… We demonstrate that this combination induces potent antitumor … A phase II trial investigating
the ability of MUC1 vaccine to … evaluated the safety and immunogenicity of a recombinant …
the ability of MUC1 vaccine to … evaluated the safety and immunogenicity of a recombinant …
[HTML][HTML] Beyond PD-1: the next frontier for immunotherapy in melanoma
A Rohatgi, JM Kirkwood - Frontiers in Oncology, 2021 - frontiersin.org
… as they can lead to reduction of antitumor cytotoxicity of T cells and … CT26 colorectal carcinoma,
monotherapy with anti-TIGIT therapy … have been tested as antiviral treatments, and now …
monotherapy with anti-TIGIT therapy … have been tested as antiviral treatments, and now …
Interferon-induced IDO1 mediates radiation resistance and is a therapeutic target in colorectal cancer
… inhibition would enhance the antitumor effects of radiation … (stage II or III) rectal cancer were
identified from published … tumor size to receive placebo, radiotherapy (6 Gy × 2), epacadostat …
identified from published … tumor size to receive placebo, radiotherapy (6 Gy × 2), epacadostat …
Trial Watch: Peptide-based anticancer vaccines
… in the clinical development of recombinant/purified TAAs or … TLR3 ligand in 46 advanced
colorectal carcinoma patients. In this … NCT00841399 (a Phase I-II study) investigated the clinical …
colorectal carcinoma patients. In this … NCT00841399 (a Phase I-II study) investigated the clinical …
Going viral with cancer immunotherapy
… ), a recombinant adenovirus, is approved for the treatment of … with other anticancer agents;
therefore, OV therapy lends itself … antiviral immune response of the patient. The most effective …
therefore, OV therapy lends itself … antiviral immune response of the patient. The most effective …
An update on Chinese herbal medicines as adjuvant treatment of anticancer therapeutics
Z Wang, F Qi, Y Cui, L Zhao, X Sun, W Tang… - Bioscience …, 2018 - jstage.jst.go.jp
… functions of anticancer, anti-inflammatory, antioxidant, antiviral and … effects in metastatic
colorectal cancer (86). Clinical … phase II study demonstrated that Cinobufacin injection, when …
colorectal cancer (86). Clinical … phase II study demonstrated that Cinobufacin injection, when …
[HTML][HTML] Current status of intralesional agents in treatment of malignant melanoma
… In a phase II study of combination therapy of IT HF10 and … , because of the defective antiviral
mechanisms in malignant cells … in the injected tumor microenvironment leading to anti-tumor …
mechanisms in malignant cells … in the injected tumor microenvironment leading to anti-tumor …
Clinical Advances and Future Directions of Oncolytic Virotherapy for Head and Neck Cancer
Z Wang, P Sun, Z Li, S Xiao - Cancers, 2023 - mdpi.com
… In a phase II clinical trial, 37 recurrent HNSCC patients … cells, resulting in heightened antitumor
effectiveness in vitro and … However, upon entry into the body, the host’s antiviral defense …
effectiveness in vitro and … However, upon entry into the body, the host’s antiviral defense …