Phenotypic conversion leads to structural and functional changes of smooth muscle sarcolemma

K Matschke, EB Babiychuk, K Monastyrskaya… - Experimental cell …, 2006 - Elsevier
… a highly organized sarcolemmal structure. Yet, smooth muscle cells also adapt rapidly to
altered environmental cues. Their sarcolemmal plasticity must lead to profound changes which …

Phenotype and functional plasticity of airway smooth muscle: role of caveolae and caveolins

AJ Halayko, T Tran, R Gosens - Proceedings of the American …, 2008 - atsjournals.org
… protein that integrates with the sarcolemma via two membrane … transcription and translation
of phenotype marker proteins are … phenotype or to follow a maturation process leading to the …

Vascular smooth muscle cell contractile function and mechanotransduction

S Ahmed, DT Warren - Vessel Plus, 2018 - ueaeprints.uea.ac.uk
… and prevalence due to wide array of changes that occurs as a … the sarcolemma, which
causes opening of the calcium … of smooth muscle cell differentiation and phenotypic switching in …

Role of dystrophin in airway smooth muscle phenotype, contraction and lung function

P Sharma, S Basu, RW Mitchell, GL Stelmack… - PloS one, 2014 - journals.plos.org
… The absence of dystrophin leads to profound reductions in the DGC at the sarcolemma [35].
The lack of structural support at the sarcolemma leaves muscle atrophic, weaker and more …

Regulation of smooth muscle excitation and contraction

KM Sanders - Neurogastroenterology & Motility, 2008 - Wiley Online Library
… in cellular phenotypes in different smooth muscles within a … phenotypic transformation.
The extent to which phenotypic … might eventually lead to functional smooth muscle cultures or …

Mutation-based therapeutic strategies for Duchenne muscular dystrophy: from genetic diagnosis to therapy

A Nakamura - Journal of personalized medicine, 2019 - mdpi.com
… in skeletal, cardiac, and smooth muscles as well as in the … converted phenotype following
exon skipping therapy due to … at the sarcolemma and improvements in skeletal muscle function. …

Smooth muscle cell heterogeneity: patterns of gene expression in vascular smooth muscle cells in vitro and in vivo

CM Shanahan, PL Weissberg - Arteriosclerosis, thrombosis, and …, 1998 - Am Heart Assoc
… vascular smooth muscle cells (VSMCs) exhibited two distinct phenotypes and that a change
… expression is likely to lead to the ability to manipulate VSMC phenotype. However, before …

[HTML][HTML] Disruption of the sarcoglycan–sarcospan complex in vascular smooth muscle: a novel mechanism for cardiomyopathy and muscular dystrophy

R Coral-Vazquez, RD Cohn, SA Moore, JA Hill… - Cell, 1999 - cell.com
… mutation and the clinical phenotype of cardiomyopathy has not … complex in smooth muscle
of coronary arteries indeed leads to … at the sarcolemma of skeletal and cardiac muscle, the …

Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation

P Sharma, T Tran, GL Stelmack… - … of Physiology-Lung …, 2008 - journals.physiology.org
sarcolemma, linking the actin cytoskeleton and extracellular matrix. The DGC is expressed in
smooth muscle tissue, but its functionalleads to DGC disruption, rendering the sarcolemma

Serum deprivation induces a unique hypercontractile phenotype of cultured smooth muscle cells

X Ma, Y Wang, NL Stephens - American Journal of …, 1998 - journals.physiology.org
Phenotypic changes seen indicated conversion to a synthetic… that control smooth muscle
differentiation, due in part to the … with smooth and phase-lucent sarcolemmal membranes as …