Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression

MLS Lindegaard, P Damm, ER Mathiesen… - Journal of lipid …, 2006 - ASBMB
… To examine whether maternal type 1 diabetes affects placental lipid metabolism, we … and
mRNA expression of lipase-encoding genes in placentas from women with type 1 diabetes (n = …

Placental accumulation of triacylglycerols in gestational diabetes mellitus and its association with altered fetal growth are related to the differential expressions of …

M Balachandiran, Z Bobby, G Dorairajan… - … & Diabetes, 2021 - thieme-connect.com
associated TG requires placental lipases such as endothelial … of triacylglycerol per milligram
of total placental proteins [24]. … of women with type 1 diabetes mellitus has been reported [56…

Expression of placental lipid transporters in pregnancies complicated by gestational and type 1 diabetes mellitus

PJ Stanirowski, M Wątroba, M Pyzlak… - International Journal of …, 2024 - mdpi.com
… a significant decrease in the EL mRNA expression among lean-GDM women [… Placental
triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene

Differential regulation of genes for fetoplacental lipid pathways in pregnancy with gestational and type 1 diabetes mellitus

T Radaelli, J Lepercq, A Varastehpour, S Basu… - American journal of …, 2009 - Elsevier
Placentas of women with type 1 diabetes mellitus, … only a minor role in triglyceride accumulation
through de novo lipid … Increased expression of the endothelial lipase LIPG2 provides …

Maternal high-fat feeding increases placental lipoprotein lipase activity by reducing SIRT1 expression in mice

L Qiao, Z Guo, C Bosco, S Guidotti, Y Wang… - Diabetes, 2015 - Am Diabetes Assoc
… compared gene expression profiles between placentas from … found that expression of
rate-limiting enzymes of triacylglycerol … that maternal HF feeding increases fetal fat accumulation. …

Placental lipases in pregnancies complicated by gestational diabetes mellitus (GDM)

HL Barrett, MH Kubala, K Scholz Romero, KJ Denny… - … One, 2014 - journals.plos.org
… Adipose triglyceride lipase (ATGL) expression has not been … increased HSL mRNA expression
in placentae from women with … lipase activity has been examined in type 1 diabetes (11 …

Placental lipoprotein lipase DNA methylation levels are associated with gestational diabetes mellitus and maternal and cord blood lipid profiles

AA Houde, J St-Pierre, MF Hivert… - … origins of health and …, 2014 - cambridge.org
… sufficient amounts of essential fatty acids, relies on maternal … or via placenta fatty acid
binding proteins,2 triglycerides (TG) … , pre-gestational type 1 or 2 diabetes, polycystic ovary …

Placental lipid transport and content in response to maternal overweight and gestational diabetes mellitus in human term placenta

L Song, N Wang, Y Peng, B Sun, W Cui - Nutrition, Metabolism and …, 2022 - Elsevier
… In the maternal circulation, plasma lipoprotein, triglyceride (… obesity is associated with higher
placental lipid accumulation … Moreover, the placental transport capacity and lipase activity …

Dynamic regulation of lipid metabolism in the placenta of in vitro and in vivo models of gestational diabetes mellitus

SY Kim, YJ Lee, SM An, MJ Kim, JS Jeong… - Biology of …, 2022 - academic.oup.com
… -sensitive lipase and expression of adipose triglyceride lipase. … We examined the mRNA
expression of hPL and GLUT1, … TG accumulation in maternal and fetal placenta. In general, TG …

The effect of high glucose on lipid metabolism in the human placenta

CH Hulme, A Nicolaou, SA Murphy, AEP Heazell… - Scientific reports, 2019 - nature.com
… with type 1 diabetes (T1DM), type 2 diabetes (T2DM), gestational … evidence of altered lipase
expression in placentas exposed, … that high glucose leads to increased placental triglyceride