… Diabetes was induced artificially by streptozotocin (STZ). … significant reduction of necrosis
and regeneration of β-cells. … of diabetes for their less toxicity and board spectrum management …

… was observed in streptozotocin (STZ) induced diabetic male … Products obtained from honey
bee including propolis, royal jelly, … Destruction in pancreatic β-cells caused by streptozotocin …

… concentration causes the rapid destruction of β cells. In contrast, STZ enters the β cell via
a … Furthermore, streptozotocin liberates toxic amounts of nitric oxide that inhibits aconitase …

… Dysregulated autophagy in pancreatic β cells due to hyperglycemia, oxidative stress, and …
the effect of propolis in enhancing the healing of cutaneous wounds in STZ-induced diabetic …

… STZ is well known to cause pancreatic B-cell damage, … to rats to partially protect insulin-secreting
cells against STZ. … moiety of STZ (methylnitrosourea) is responsible for the toxicity of this …

… and dysfunction in pancreatic β-cells. In healthy individuals, β-cells produce insulin which is
a … In individuals with T2D, the β-cells are either dysfunctional or their mass is reduced, thus …

… The mechanism of the action of STZ on pancreatic β-cells has … development of complications
from STZ (Sadek et al., 2017). … Carboxylic radicals, which are highly reactive, produce toxic …

… In acute exposure experiments, the INS-1 pancreatic β-cells … in both normal and streptozotocin
(STZ)-induced diabetic rats … of the major components of honeybee propolis. CAPE (5 μM/…

… To create the diabetes in rats, 45 mg/kg single-dose streptozotocin (STZ) was administered
ip … can protect the β-cells in pancreatic islets of Langerhans from the harmful effects of STZ. …

… a synergistic activity against oxidative stress and LPO in pancreatic tissues of STZ-control
animals. … and MDA in the pancreatic homogenates may protect β-cells against ROS and LPO. …