Synapsin regulation of vesicle organization and functional pools

M Bykhovskaia - Seminars in cell & developmental biology, 2011 - Elsevier
… (brown) vesicle pools at hippocampal synapses are intermixed within a cluster… deletion
significantly reduced exocytosis, but not the density of docked vesicles at synapses lacking Rab3a

Membrane traffic in the secretory pathway: Regulation of secretory vesicle traffic by Rab small GTPases

M Fukuda - Cellular and Molecular Life Sciences, 2008 - Springer
… (but see [47]; Rab3A deletion reduced vesicle docking at the … of the mouse stomach, and
deletion of Slp2-a reduces both … , a greatly reduced number of synaptic vesicles docked to the …

Synapsin II and Rab3a cooperate in the regulation of epileptic and synaptic activity in the CA1 region of the hippocampus

P Feliciano, R Andrade… - Journal of Neuroscience, 2013 - Soc Neuroscience
… Here, we show that Rab3a gene deletion rescues the overexcitable phenotype … )
Rab3a-mediated vesicle recruitment regulates short-term plasticity at the mouse diaphragm synapse. …

Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity

OM Schlüter, J Basu, TC Südhof… - Journal of …, 2006 - Soc Neuroscience
release indicate that Rab3 acts on a subset of primed, fusion … of vesicular release probability,
we used quadruple Rab3A, … was not caused by the removal of Rab3a alone, because we …

[PDF][PDF] RIM determines Ca2+ channel density and vesicle docking at the presynaptic active zone

Y Han, PS Kaeser, TC Südhof, R Schneggenburger - Neuron, 2011 - cell.com
… conditional removal of RIM proteins leads to a strong decrease of … functions that ensure fast
rates of transmitter release at synapses. … Single Rab3A KO mice exhibit a deficit in the activity-…

[HTML][HTML] Synapsin I accelerates kinetics of neurotransmitter release in mouse motor terminals

WL Coleman, M Bykhovskaia - Synapse (New York, NY), 2009 - ncbi.nlm.nih.gov
… The diaphragms of adult mice were dissected and synapticrelease kinetics was unaffected
by synapsin gene deletion. … last stages of synaptic vesicle fusion and demonstrates that …

Molecular insights into the roles of rab proteins in intracellular dynamics and neurodegenerative diseases

S Veleri, P Punnakkal, GL Dunbar, P Maiti - Neuromolecular medicine, 2018 - Springer
… ’ state is triggered by addition or deletion of a phosphate group (… They are key players in
neurotransmitter release. SV … with Rab3A and Rabphilin for synaptic vesicle docking and fusion. …

Redundant functions of RIM1α and RIM2α in Ca2+‐triggered neurotransmitter release

S Schoch, T Mittelstaedt, PS Kaeser, D Padgett… - The EMBO …, 2006 - embopress.org
… , exocytosis of transmitter‐filled synaptic vesicles at the … on the diaphragm in a discrete
spatially restricted endplate … and 2α deletion on synapse structure and neurotransmitter release. …

Synaptic assembly of the brain in the absence of neurotransmitter secretion

M Verhage, AS Maia, JJ Plomp, AB Brussaard… - Science, 2000 - science.org
Deletion of a single protein, Munc18-1, in mice leads to a complete loss of neurotransmitter
secretion from synaptic vesicles … , earlier developing synapse, we investigated the diaphragm

Impaired activity-dependent plasticity of quantal amplitude at the neuromuscular junction of Rab3A deletion and Rab3A earlybird mutant mice

X Wang, Q Wang, S Yang, M Bucan… - Journal of …, 2011 - Soc Neuroscience
Rab3A is a small GTPase associated with synaptic vesicles … of vesicles that fuse through
an effect on docking, vesiclereduced (R 2 = 0.09 and 0.12, respectively). In addition, four …